ArticleScientific reports2020
Carotid sinus nerve stimulation attenuates alveolar bone loss and inflammation in experimental periodontitis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Neural Orchestration of Mandibular Development.International dental journal · 2026Review
- The roles of the nerve-immune axis in modulating bone regeneration.Bone research · 2026Review
- Sleep deficiency exacerbates periodontal inflammation via trigeminal TRPV1 neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Neurocardiology: translational advancements and potential.The Journal of physiology · 2025Review
- Transcriptome analysis of induced pluripotent stem cells' osteogenic differentiation reveals NPY1R activating PI3K/AKT/mTOR in alveolar bone loss during periodontitis.American journal of translational research · 2025Article
- Piezoelectric stimulation enhances bone regeneration in alveolar bone defects through metabolic reprogramming of macrophages.Exploration (Beijing, China) · 2024Article
- Bioelectronic modulation of carotid sinus nerve to treat type 2 diabetes: current knowledge and future perspectives.Frontiers in neuroscience · 2024Review
- The interaction between the nervous system and the stomatognathic system: from development to diseases.International journal of oral science · 2023Review
- Neural Regulations in Tooth Development and Tooth-Periodontium Complex Homeostasis: A Literature Review.International journal of molecular sciences · 2022Review
- Peripheral nerve stimulation and immunity: the expanding opportunities for providing mechanistic insight and therapeutic intervention.International immunology · 2022Review
- Influence of direct prostheses on the condition of the alveolar processes during dental implantation.The Saudi dental journal · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Baroreceptor and chemoreceptor reflexes modulate inflammatory responses. However, whether these reflexes attenuate periodontal diseases has been poorly examined. Thus, the present study determined the effects of electrical activation of the carotid sinus nerve (CSN) in rats with periodontitis. We hypothesized that activation of the baro and chemoreflexes attenuates alveolar bone loss and the associated inflammatory processes. Electrodes were implanted around the CSN, and bilateral ligation of the first mandibular molar was performed to, respectively, stimulate the CNS and induce periodontitis. The CSN was stimulated daily for 10 min, during nine days, in unanesthetized animals. On the eighth day, a catheter was inserted into the left femoral artery and, in the next day, the arterial pressure was recorded. Effectiveness of the CNS electrical stimulation was confirmed by hypotensive responses, which was followed by the collection of a blood sample, gingival tissue, and jaw. Long-term (9 days) electrical stimulation of the CSN attenuated bone loss and the histological damage around the first molar. In addition, the CSN stimulation also reduced the gingival and plasma pro-inflammatory cytokines induced by periodontitis. Thus, CSN stimulation has a protective effect on the development of periodontal disease mitigating alveolar bone loss and inflammatory processes.
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