ArticleNature communications2020
Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Cutaneous gain-of-function mutation of LRIG3 leads to alopecia by upregulation of ERBB, PI3K/AKT, NOTCH1 signaling pathways.Scientific reports · 2026Article
- Molecular characterization and functional insights of secondary hair follicles across the cashmere growth cycle.BMC genomics · 2026Article
- Intrinsic mechanisms and microenvironmental cues fine-tune plasticity of esophageal progenitors.Nature communications · 2026Article
- MCell death & disease · 2026Article
- Cellular and molecular mechanisms of seahorse male pregnancy.Nature ecology & evolution · 2025Article
- Lifting regenerative barriers promotes epithelial cell fate plasticity supporting lineage conversion.Nature communications · 2025Article
- Rat Hair Follicle Stem Cell-Derived Exosomes: Isolation, Characterization and Comparative Analysis of Their In Vitro Wound Healing Potential.International journal of molecular sciences · 2025Article
- Multi-omics and AI-driven advances in miRNA-mediated hair follicle regulation in cashmere goats.Frontiers in veterinary science · 2025Review
- Isolation, Expansion, and Characterization of Rat Hair Follicle Stem Cells and Their Secretome: Insights into Wound Healing Potential.Biomedicines · 2024Article
- Overview of chromatin regulatory processes during surface ectodermal development and homeostasis.Developmental biology · 2024Review
- Molecular stratification of the human fetal vaginal epithelium by spatial transcriptome analysis.Acta biochimica et biophysica Sinica · 2024Article
- Human urinary cells for functional wound healing with sweat gland restoration.Military Medical Research · 2023Article
- Single-cell RNA sequencing in cornea research: Insights into limbal stem cells and their niche regulation.World journal of stem cells · 2023Review
- Analysis of the potential of human cultured nasal epithelial cell sheets to differentiate into airway epithelium.FASEB bioAdvances · 2023Article
- Mechanical force drives the initial mesenchymal-epithelial interaction during skin organoid development.Theranostics · 2023Article
- Three-Dimensional Culture Systems for Dissecting Notch Signalling in Health and Disease.International journal of molecular sciences · 2021Review
- EGF-mediated suppression of cell extrusion during mucosal damage attenuates opportunistic fungal invasion.Cell reports · 2021Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The formation of hair follicles, a landmark of mammals, requires complex mesenchymal-epithelial interactions and it is commonly believed that embryonic epidermal cells are the only cells that can respond to hair follicle morphogenetic signals in vivo. Here, we demonstrate that epithelial stem cells of non-skin origin (e.g. that of cornea, oesophagus, vagina, bladder, prostate) that express the transcription factor Tp63, a master gene for the development of epidermis and its appendages, can respond to skin morphogenetic signals. When exposed to a newborn skin microenvironment, these cells express hair-follicle lineage markers and contribute to hair follicles, sebaceous glands and/or epidermis renewal. Our results demonstrate that lineage restriction is not immutable and support the notion that all Tp63-expressing epithelial stem cells, independently of their embryonic origin, have latent skin competence explaining why aberrant hair follicles or sebaceous glands are sometimes observed in non-skin tissues (e.g. in cornea, vagina or thymus).
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