ArticleNature communications2020
Dermal IRF4+ dendritic cells and monocytes license CD4+ T helper cells to distinct cytokine profiles.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Epidermal PPARγ Signaling as a Suppressor of Toll-like Receptor-Mediated Inflammation and Fibrosis: Relevance to Cutaneous Squamous Cell Carcinoma.International journal of molecular sciences · 2026Article
- Dendritic Cell Organization and Function in Innate and Adaptive Immune Defense Within Lymph Nodes.Immunological reviews · 2026Review
- Functional Specialization and Collaboration of cDC2 Subsets in CD4+ T Cell Priming and Differentiation.Immunological reviews · 2025Review
- Dendritic cells steering antigen and leukocyte traffic in lymph nodes.FEBS letters · 2025Review
- Antisense oligonucleotides targeting IRF4 alleviate psoriasis.Acta pharmaceutica Sinica. B · 2025Article
- CD301bNature communications · 2025Article
- How type-2 dendritic cells induce Th2 differentiation: Instruction, repression, or fostering T cell-T cell communication?Allergy · 2025Review
- Targeting persistently activated inflammatory microenvironment to promote chronic wound healing.Frontiers in immunology · 2025Review
- Site-specific regulation of Th2 differentiation within lymph node microenvironments.The Journal of experimental medicine · 2024Article
- Transformable nano-antibiotics for mechanotherapy and immune activation against drug-resistant Gram-negative bacteria.Science advances · 2023Article
- Distinct defects in early innate and late adaptive immune responses typify impaired fracture healing in diet-induced obesity.Frontiers in immunology · 2023Article
- Information flow in the spatiotemporal organization of immune responses.Immunological reviews · 2022Review
- Understanding the development of Th2 cell-driven allergic airway disease in early life.Frontiers in allergy · 2022Review
- Basophils control T cell priming through soluble mediators rather than antigen presentation.Frontiers in immunology · 2022Review
- The Sympathetic Nervous System Modulates Cancer Vaccine Activity through Monocyte-Derived Cells.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Homeostatic IL-13 in healthy skin directs dendritic cell differentiation to promote TNature immunology · 2021Article
- Conversations that count: Cellular interactions that drive T cell fate.Immunological reviews · 2021Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Antigen (Ag)-presenting cells (APC) instruct CD4+ helper T (Th) cell responses, but it is unclear whether different APC subsets contribute uniquely in determining Th differentiation in pathogen-specific settings. Here, we use skin-relevant, fluorescently-labeled bacterial, helminth or fungal pathogens to track and characterize the APC populations that drive Th responses in vivo. All pathogens are taken up by a population of IRF4+ dermal migratory dendritic cells (migDC2) that similarly upregulate surface co-stimulatory molecules but express pathogen-specific cytokine and chemokine transcripts. Depletion of migDC2 reduces the amount of Ag in lymph node and the development of IFNγ, IL-4 and IL-17A responses without gain of other cytokine responses. Ag+ monocytes are an essential source of IL-12 for both innate and adaptive IFNγ production, and inhibit follicular Th cell development. Our results thus suggest that Th cell differentiation does not require specialized APC subsets, but is driven by inducible and pathogen-specific transcriptional programs in Ag+ migDC2 and monocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.