ArticleTranslational psychiatry2020
Evidence in cortical folding patterns for prenatal predispositions to hallucinations in schizophrenia.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Evaluation of a New Paracingulate Sulcus Identification and Measurement Protocol.Human brain mapping · 2026Article
- Genetic insights on the mechanisms of human cortical folding.bioRxiv : the preprint server for biology · 2026Article
- Reassessing Asymmetry Reduction in Psychosis: Cingulate Folding and Gyrification Covariance in Patients with Auditory Hallucinations.Schizophrenia bulletin · 2026Article
- Variable Presence of an Evolutionarily New Brain Structure Is Related to Trait Impulsivity.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Asymmetric Cingulum Bundle Connectivity Is Modulated by Paracingulate Sulcus Morphology.Human brain mapping · 2025Article
- Variable Presence of an Evolutionarily New Brain Structure is Related to Trait Impulsivity.bioRxiv : the preprint server for biology · 2024Article
- Machine learning in small sample neuroimaging studies: Novel measures for schizophrenia analysis.Human brain mapping · 2024Article
- Sulcal variability in anterior lateral prefrontal cortex contributes to variability in reasoning performance among young adults.Brain structure & function · 2024Article
- A multiscale characterization of cortical shape asymmetries in early psychosis.Brain communications · 2024Article
- Sulcal pits of the superior temporal sulcus in schizophrenia patients with auditory verbal hallucinations.AIMS neuroscience · 2024Article
- Neuroanatomical and Functional Dissociations between Variably Present Anterior Lateral Prefrontal Sulci.Journal of cognitive neuroscience · 2023Article
- Integrated lipidomic and transcriptomic analysis reveals clarithromycin-induced alteration of glycerophospholipid metabolism in the cerebral cortex of mice.Cell biology and toxicology · 2023Article
- Paracingulate Sulcus Length and Cortical Thickness in Schizophrenia Patients With and Without a Lifetime History of Auditory Hallucinations.Schizophrenia bulletin · 2023Article
- Novel Gyrification Networks Reveal Links with Psychiatric Risk Factors in Early Illness.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Article
- Sexually dimorphic neuroanatomical differences relate to ASD-relevant behavioral outcomes in a maternal autoantibody mouse model.Molecular psychiatry · 2021Article
- Neuroanatomical correlates of reality monitoring in patients with schizophrenia and auditory hallucinations.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Revisiting the Morphology and Classification of the Paracingulate Gyrus with Commentaries on Ambiguous Cases.Brain sciences · 2021Article
- Overlooked Tertiary Sulci Serve as a Meso-Scale Link between Microstructural and Functional Properties of Human Lateral Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Towards Deciphering the Fetal Foundation of Normal Cognition and Cognitive Symptoms From Sulcation of the Cortex.Frontiers in neuroanatomy · 2021Article
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Authors and funding
17 authors at 8 institutions in 3 countries.
Funding
Abstract
All perception is a construction of the brain from sensory input. Our first perceptions begin during gestation, making fetal brain development fundamental to how we experience a diverse world. Hallucinations are percepts without origin in physical reality that occur in health and disease. Despite longstanding research on the brain structures supporting hallucinations and on perinatal contributions to the pathophysiology of schizophrenia, what links these two distinct lines of research remains unclear. Sulcal patterns derived from structural magnetic resonance (MR) images can provide a proxy in adulthood for early brain development. We studied two independent datasets of patients with schizophrenia who underwent clinical assessment and 3T MR imaging from the United Kingdom and Shanghai, China (n = 181 combined) and 63 healthy controls from Shanghai. Participants were stratified into those with (n = 79 UK; n = 22 Shanghai) and without (n = 43 UK; n = 37 Shanghai) hallucinations from the PANSS P3 scores for hallucinatory behaviour. We quantified the length, depth, and asymmetry indices of the paracingulate and superior temporal sulci (PCS, STS), which have previously been associated with hallucinations in schizophrenia, and constructed cortical folding covariance matrices organized by large-scale functional networks. In both ethnic groups, we demonstrated a significantly shorter left PCS in patients with hallucinations compared to those without, and to healthy controls. Reduced PCS length and STS depth corresponded to focal deviations in their geometry and to significantly increased covariance within and between areas of the salience and auditory networks. The discovery of neurodevelopmental alterations contributing to hallucinations establishes testable models for these enigmatic, sometimes highly distressing, perceptions and provides mechanistic insight into the pathological consequences of prenatal origins.
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