ArticleTranslational psychiatry2020
Fractionating autism based on neuroanatomical normative modeling.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07699159 (Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions), which is not on this map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cohort Network for Adolescents and Youth With multipLe Mental Health Conditions (CALM): A Master Observational Trial
Who cites it
49 citing papers in PubMed.
- Gray matter subtyping with SuStaIn reveals neuroanatomical patterns in autism spectrum disorder.Brain imaging and behavior · 2026Article
- Motifs of brain cortical folding from birth to adulthood.Nature communications · 2026Article
- Heterogeneous functional state dynamics and its structural substrates in male individuals with autism spectrum disorder.Molecular psychiatry · 2026Article
- From heterogeneity to translation: data‑driven subtyping of autism in a multilevel framework.Translational psychiatry · 2026Review
- Empirical validation of race-neutral normative brain morphometry models across ethnoracially diverse populations.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Advantages of combining multiple eye-tracking paradigms for distinguishing young autistic from non-autistic children.Molecular autism · 2026Article
- Normative modeling reveals functional connectivity heterogeneity in internet gaming disorder.Annals of general psychiatry · 2026Article
- Normative Modeling of Static and Dynamic Functional Connectivity.bioRxiv : the preprint server for biology · 2026Article
- The influence of sample size and covariate distributions on neuroanatomical normative modeling.eLife · 2026Article
- Generating Biologically Relevant Subtypes of Autism Spectrum Disorder with differential responses to Acute Oxytocin Administration in a Randomized Trial using Random Forest Models and K-means Clustering.medRxiv : the preprint server for health sciences · 2026Article
- Predicting developmental norms from baseline cortical thickness in longitudinal studies.Biology of sex differences · 2026Article
- Subtyping Autism Spectrum Disorder With a Population Graph-Based Dual Autoencoder: Revealing Two Distinct Biotypes.CNS neuroscience & therapeutics · 2025Article
- The normative modelling framework for traumatic brain injury.Brain : a journal of neurology · 2025Review
- Understanding individual neurodegenerative progression in Parkinson's disease through normative modelling.Scientific reports · 2025Article
- Neuroanatomical normative modelling in frontotemporal lobar degeneration: higher heterogeneity in the behavioural variant.Journal of neurology · 2025Article
- Neural correlates of human fear conditioning and sources of variability in 2199 individuals.Nature communications · 2025Article
- Profiling brain morphology for autism spectrum disorder with two cross-culture large-scale consortia.Communications biology · 2025Article
- Using Extreme Value Statistics to Reconceptualize Psychopathology as Extreme Deviations From a Normative Reference Model.Human brain mapping · 2025Article
- Transcriptomic decoding of surface-based imaging phenotypes and its application to pharmacotranscriptomics.Nature communications · 2025Article
- Beyond homogeneity: charting the landscape of heterogeneity in neurodevelopmental and psychiatric electroencephalography.Translational psychiatry · 2025Article
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
Autism is a complex neurodevelopmental condition with substantial phenotypic, biological, and etiologic heterogeneity. It remains a challenge to identify biomarkers to stratify autism into replicable cognitive or biological subtypes. Here, we aim to introduce a novel methodological framework for parsing neuroanatomical subtypes within a large cohort of individuals with autism. We used cortical thickness (CT) in a large and well-characterized sample of 316 participants with autism (88 female, age mean: 17.2 ± 5.7) and 206 with neurotypical development (79 female, age mean: 17.5 ± 6.1) aged 6-31 years across six sites from the EU-AIMS multi-center Longitudinal European Autism Project. Five biologically based putative subtypes were derived using normative modeling of CT and spectral clustering. Three of these clusters showed relatively widespread decreased CT and two showed relatively increased CT. These subtypes showed morphometric differences from one another, providing a potential explanation for inconsistent case-control findings in autism, and loaded differentially and more strongly onto symptoms and polygenic risk, indicating a dilution of clinical effects across heterogeneous cohorts. Our results provide an important step towards parsing the heterogeneous neurobiology of autism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.