Evidence map›Paper›PMID 33158978›Full record

ArticleLife science alliance2021

Interferon lambda 4 can directly activate human CD19

Mairene Coto-Llerena, Marco Lepore, Julian Spagnuolo, Daniela Di Blasi, Diego Calabrese, Aleksei Suslov, Glenn Bantug, Francois Ht Duong, Luigi M Terracciano, Gennaro De Libero and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mairene Coto-LlerenaDepartment of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland.
Marco LeporeDepartment of Biomedicine, Experimental Immunology, University Hospital and University of Basel, Basel, Switzerland.
Julian SpagnuoloDepartment of Biomedicine, Experimental Immunology, University Hospital and University of Basel, Basel, Switzerland.ORCID 0000-0002-7580-173X
Daniela Di BlasiDepartment of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland.
Diego CalabreseDepartment of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland.ORCID 0000-0002-0259-8611
Aleksei SuslovDepartment of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland.
Glenn BantugDepartment of Biomedicine, Immunobiology, University Hospital and University of Basel, Basel, Switzerland.
Francois Ht DuongDepartment of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland.
Luigi M TerraccianoMolecular Pathology Division, Institute of Pathology, University Hospital Basel, Basel, Switzerland.
Gennaro De LiberoDepartment of Biomedicine, Experimental Immunology, University Hospital and University of Basel, Basel, Switzerland gennaro.delibero@unibas.ch.ORCID 0000-0003-0853-7868
Markus H HeimDepartment of Biomedicine, Hepatology, University Hospital and University of Basel, Basel, Switzerland markus.heim@unibas.ch.ORCID 0000-0002-7523-4894
University of Basel · CHUniversity Hospital of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compared with the ubiquitous expression of type I (IFNα and IFNβ) interferon receptors, type III (IFNλ) interferon receptors are mainly expressed in epithelial cells of mucosal barriers of the of the intestine and respiratory tract. Consequently, IFNλs are important for innate pathogen defense in the lung and intestine. IFNλs also determine the outcome of hepatitis C virus (HCV) infections, with IFNλ4 inhibiting spontaneous clearance of HCV. Because viral clearance is dependent on T cells, we explored if IFNλs can directly bind to and regulate human T cells. We found that human B cells and CD8

Indexed as

HepacivirusAdolescentAdultAgedAntigens, CD19Blood DonorsB-LymphocytesCD8-Positive T-LymphocytesFemaleHepatitis CHumansInterferon-alphaInterferon LambdaInterferonsInterleukinsLymphocyte ActivationAntigens, CD19CD19 molecule, humanIFNL4 protein, humanInterferon-alphaInterferon Lambdainterferon-lambda, humanInterferonsInterleukinsReceptors, Interferon

Identifiers

PMID33158978
PMCPMC7668538
OpenAlexW3095477870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.