ArticleScience immunology2020
Tissue-resident CD8
Open access · greenAbstract read
In one paragraph
Article in Science immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers.
0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed
7.7field-weighted citation impact, top 2% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
104 citing papers in PubMed, 147 citations in OpenAlex.
- Development and validation of a nomogram model for prediction of stroke-associated pneumonia associated with intracerebral hemorrhage.BMC geriatrics · 2023Trial
- Immune signatures underlying post-acute COVID-19 lung sequelae.Science immunology · 2021Trial
- Pre-existing and cross-reactive immunity to avian influenza H5N1 in humans: Implications for pandemic risk and vaccine strategies.The Journal of infection · 2026Review
- The immunology behind inflammaging-causes, sources, and mechanisms.The Journal of allergy and clinical immunology · 2026Review
- The ageing immune system and its battle with viruses.The Journal of general virology · 2026Review
- Temporal Dissection of TGF-β signaling reveals differential impact during female reproductive mucosal CD8 resident memory T cell differentiation.Mucosal immunology · 2026Article
- Respiratory Microbiome Remodeling in Aging: Implications for Immunosenescence and Therapeutic Intervention.Immune network · 2026Review
- Aberrant activation of tissue-resident lymphocytes and pro-fibrotic GZMK⁺ CD8⁺ T cells in IPF.Communications biology · 2026Article
- Astrocytic but not Microglial Antigen Presentation Shapes Protective Immunity to Toxoplasma gondii in the Brain.Research square · 2026Article
- Nasal CD4+ tissue-resident memory T cells provide cross-protective immunity to influenza.The Journal of experimental medicine · 2026Article
- Review
- Immune modulatory vaccines targeting tumor microenvironment antigens: recent advances in oncology and beyond.Signal transduction and targeted therapy · 2026Review
- Dysplastic Epithelial Repair Propagates Chronic Pathology Through the Paracrine Transformation of Pulmonary Fibroblasts.bioRxiv : the preprint server for biology · 2026Article
- Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma.Mucosal immunology · 2026Article
- Senolytic Treatment Reduces Acute and Chronic Lung Inflammation in an Aged Mouse Model of Influenza.Aging cell · 2026Article
- In vivo labeling reveals that degranulation is increased under supraphysiological TCR stimulation, but not infection, in CD8GeroScience · 2026Article
- CD27 and ICOS as Targets of PD-1/PD-L1 Signaling to Regulate Resident Memory CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Age-dependent immune landscapes affect influenza vaccine effectiveness and guide precision strategies.Frontiers in immunology · 2026Review
- Mechano-immune interactions in musculoskeletal aging: Mechanisms and translational perspectives.Theranostics · 2026Review
- Antigen-specific CD8 T cells are generated and reactivated in the bone marrow following viral brain infections and impact the bone marrow niche.bioRxiv : the preprint server for biology · 2025Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on bySeedy CD8+ T2021
Authors and funding
15 authors at 2 institutions in 1 country.
Nick P GoplenDivision of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-4614-5996
Yue WuDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-3667-2960
Young Min SonDivision of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-2978-8703
Chaofan LiDivision of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Zheng WangDivision of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-6002-5299
In Su CheonDivision of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Li JiangDivision of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-2169-8773
Bibo ZhuDivision of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Katayoun AyasoufiDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
Eduardo N ChiniThe Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN 55905, USA.
Aaron J JohnsonDepartment of Immunology, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0002-7921-484X
Robert VassalloDivision of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-2328-0255
Andrew H LimperDivision of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Nu ZhangLong School of Medicine, Departments of Microbiology, Immunology, and Molecular Genetics, University of Texas Health San Antonio, San Antonio, TX 78229, USA.ORCID 0000-0001-9695-210X
Jie SunDivision of Pulmonary and Critical Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA. sun.jie@mayo.edu.ORCID 0000-0002-2347-4511
Mayo Clinic · USThe University of Texas Health Science Center at San Antonio · US
Funding
Host cellular network governing the development of post SARS-CoV-2 tissue sequelaeR01AI147394 · NIAID · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$4.7MCD8 T cell mediated disruption of Blood Brain Barrier Tight JunctionsR01NS103212 · NINDS · MAYO CLINIC ROCHESTER · PI Aaron J Johnson · 2017 to 2026
$4.6MMolecular regulation of protective CD8 immunity against influenza infectionR01AI112844 · NIAID · UNIVERSITY OF VIRGINIA · PI SUN, JIE · 2015 to 2024
$4.5MElucidating the roles of alveolar macrophage inflammation and selfrenewal during influenza infectionR01AG069264 · NIA · UNIVERSITY OF VIRGINIA · PI Jie Sun · 2020 to 2026
$3.5MTherapeutic implication of CD38 in CLLR01CA233790 · NCI · MAYO CLINIC JACKSONVILLE · PI CHINI, EDUARDO N · 2019 to 2023
$3.0MRole of CD38 in NAD metabolism: from the basic biology of aging to translationR01AG058812 · NIA · MAYO CLINIC ROCHESTER · PI CHINI, EDUARDO N · 2018 to 2022
$2.0MMechanistic study of TGF-beta-dependent control of gut-resident memory T cellsR01AI125701 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHANG, NU · 2016 to 2020
$2.0MSimultaneously boosting both humoral and cellular immunity following vaccinationR01AG047156 · NIA · MAYO CLINIC ROCHESTER · PI SUN, JIE · 2015 to 2019
$1.6MResearch Training Program in Neuro-OncologyT32CA217836 · NCI · MAYO CLINIC ROCHESTER · PI O'NEILL, BRIAN PATRICK, VILE, RICHARD G. · 2018 to 2022
$1.4MPostdoctoral Training Program for Research on AgingT32AG049672 · NIA · MAYO CLINIC ROCHESTER · PI PASSOS, JOAO · 2016 to 2022
$1.3MMechanistic studies of Tissue-resident T cell maturation in the kidneyR21AI139721 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHANG, NU · 2018 to 2019
$419kNCI NIH HHS R01 CA233790NCI NIH HHS T32 CA217836NIAID NIH HHS R01 AI112844NIAID NIH HHS R01 AI125701NIAID NIH HHS R01 AI147394NIAID NIH HHS R21 AI139721NIA NIH HHS R01 AG047156NIA NIH HHS R01 AG058812NIA NIH HHS R01 AG069264NIA NIH HHS T32 AG049672NIH HHS AG047156NIH HHS AG069264NIH HHS AI112844NIH HHS AI125701NIH HHS AI139721NIH HHS AI147394NIH HHS HL52160NIH HHS NS103212NIH HHS T32AG04967NINDS NIH HHS R01 NS103212
Abstract
Lower respiratory viral infections, such as influenza virus and severe acute respiratory syndrome coronavirus 2 infections, often cause severe viral pneumonia in aged individuals. Here, we report that influenza viral pneumonia leads to chronic nonresolving lung pathology and exacerbated accumulation of CD8
Indexed as
Age FactorsAnimalsCD8-Positive T-LymphocytesCOVID-19Host-Pathogen InteractionsHumansImmunologic MemoryInfluenza, HumanLungMice, Inbred C57BLOrthomyxoviridaeOrthomyxoviridae InfectionsPandemicsPneumonia, ViralSARS-CoV-2Transforming Growth Factor betaTransforming Growth Factor beta
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.