ArticleArchives of disease in childhood. Fetal and neonatal edition2021
Survival and causes of death in extremely preterm infants in the Netherlands.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Causes of neonatal mortality in the European Economic Area and Switzerland: a WHO-based analysis and systematic review.European journal of pediatrics · 2025Pooled it
- Survival outcomes among periviable infants: a systematic review and meta-analysis comparing different income countries and time periods.Frontiers in public health · 2024Pooled it
- Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review.Neonatology · 2023Pooled it
- Trial
- Factors associated with survival of extremely preterm infants and development of a nomogram: a 9-year single-center study in China.Scientific reports · 2026Article
- Artificial womb technology; a scoping review of ethical considerations.Journal of perinatology : official journal of the California Perinatal Association · 2026Review
- Preterm Neonatal Mortality and Its Associated Factors in Ethiopia: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Is small for gestational age associated with reduced oxygen saturation to FiOEuropean journal of pediatrics · 2026Article
- Survival and Causes of Death in Infants Admitted in NICU in Iran: A Retrospective Cohort Study 2016-2022.Iranian journal of public health · 2025Article
- [Impact of different treatment attitudes on survival and risk factors for poor clinical outcomes in extremely preterm infants: a retrospective real-world study].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Article
- Neonatal Training across Union of European Medical Specialists Member Countries: A Survey from the Next Generation of Neonatologists.Neonatology · 2025Article
- A Retrospective Multicenter Stratified Study on Perinatal Factors Influencing Neonatal Mortality in Preterm Infants in Kazakhstan.International journal of pediatrics · 2025Article
- Mother's own milk and bronchopulmonary dysplasia in appropriate for gestational age preterm infants.European journal of clinical nutrition · 2024Article
- The global burden of disease attributable to preterm birth and low birth weight in 204 countries and territories from 1990 to 2019: An analysis of the Global Burden of Disease Study.Journal of global health · 2024Article
- Noninvasive pressure-strain loop quantitative assessment of left ventricular function in anemic preterm infants with different modes of respiratory support.The international journal of cardiovascular imaging · 2024Article
- Gut development following insulin-like growth factor-1 supplementation to preterm pigs.Pediatric research · 2024Article
- Neurodevelopmental outcome at 5.5 years in Dutch preterm infants born at 24-26 weeks' gestational age: the EPI-DAF study.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
- Identifying immune signatures of sepsis to increase diagnostic accuracy in very preterm babies.Nature communications · 2024Article
- ERS International Congress 2023: highlights from the Paediatrics Assembly.ERJ open research · 2024Article
- Cerebral Oximetry in the Neonatal Intensive Care Unit: Discussion of Two Contradicting Study Results (SafeBoosC-II, SafeBoosC-III).Advances in experimental medicine and biology · 2024Article
Corrections and comments
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Authors and funding
14 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn the Netherlands, the threshold for offering active treatment for spontaneous birth was lowered from 25
designNational cohort study, using data from the Netherlands Perinatal Registry. PATIENTS: The study population included all 3312 stillborn and live born infants with a gestational age (GA) between 24
main outcome measuresSurvival to discharge, as well as cause and timing of death.
resultsAfter guideline implementation, there was a significant increase in neonatal intensive care unit (NICU) admission rate for live born infants born at 24 weeks' GA (27%-69%, p<0.001), resulting in increased survival to discharge in 24-week live born infants (13%-34%, p<0.001). Top three causes of in-hospital mortality were necrotising enterocolitis (28%), respiratory distress syndrome (19%) and intraventricular haemorrhage (17%). A significant decrease in cause of death either complicated or caused by respiratory insufficiency was seen over time (34% in 2011-2014 to 23% in 2015-2017, p=0.006).
conclusionsImplementation of the 2010 guideline resulted as expected in increased NICU admissions rate and postnatal survival of infants born at 24 weeks' GA. In the years after implementation, a shift in cause of death was seen from respiratory insufficiency towards necrotising enterocolitis and sepsis.
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