Evidence map›Paper›PMID 33158970›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Structure of a protective epitope reveals the importance of acetylation of

Pedro Henriques, Lucia Dello Iacono, Ana Gimeno, Alessia Biolchi, Maria Rosaria Romano, Ana Arda, Gonҫalo J L Bernardes, Jesus Jimenez-Barbero, Francesco Berti, Rino Rappuoli and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Outsmarting Pathogens with Antibody Engineering.Annual review of chemical and biomolecular engineering · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Strategies to Tackle Antimicrobial Resistance: The Example ofInternational journal of molecular sciences · 2021
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pedro HenriquesInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
Lucia Dello IaconoResearch and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy.
Ana GimenoChemical Glycobiology Lab CIC bioGUNE Technology Park, 48160 Derio, Spain.ORCID 0000-0001-9668-2605
Alessia BiolchiResearch and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy.ORCID 0000-0001-5104-5522
Maria Rosaria RomanoResearch and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy.
Ana ArdaChemical Glycobiology Lab CIC bioGUNE Technology Park, 48160 Derio, Spain.
Gonҫalo J L BernardesInstituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
Jesus Jimenez-BarberoChemical Glycobiology Lab CIC bioGUNE Technology Park, 48160 Derio, Spain.ORCID 0000-0001-5421-8513
Francesco BertiResearch and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy.
Rino RappuoliResearch and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy; rino.r.rappuoli@gsk.com roberto.x.adamo@gsk.com.ORCID 0000-0002-8827-254X
Roberto AdamoResearch and Development Centre, GlaxoSmithKline (GSK), 53100 Siena, Italy; rino.r.rappuoli@gsk.com roberto.x.adamo@gsk.com.ORCID 0000-0001-5228-6088

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meningococcal meningitis remains a substantial cause of mortality and morbidity worldwide. Until recently, countries in the African meningitis belt were susceptible to devastating outbreaks, largely attributed to serogroup A

Indexed as

AcetylationAdolescentAntibodies, BacterialChildClinical Trials, Phase II as TopicCrystallography, X-RayEpitopesFemaleHumansImmunogenicity, VaccineImmunoglobulin Fab FragmentsMaleMeningitis, MeningococcalMeningococcal VaccinesMolecular Docking SimulationMulticenter Studies as TopicAntibodies, BacterialEpitopesImmunoglobulin Fab FragmentsMenACWY-CRM vaccineMeningococcal VaccinesPolysaccharides, BacterialVaccines, ConjugatecarbohydratesNeisseria meningitidisstructural glycobiologyvaccines

Identifiers

PMID33158970
PMCPMC7703565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.