Evidence map›Paper›PMID 33158963›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

CaMKIIα-Positive Interneurons Identified via a microRNA-Based Viral Gene Targeting Strategy.

Marianna K Keaveney, Bahar Rahsepar, Hua-An Tseng, Fernando R Fernandez, Rebecca A Mount, Tina Ta, John A White, Jim Berg, Xue Han

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  4. Optogenetic Hedonic Hotspots in the Orbitofrontal Cortex and Insula: Causing Enhancement of Sweetness "Liking".The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  11. A Neural Circuit For Bergamot Essential Oil-Induced Anxiolytic Effects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  12. Focal postnatal deletion ofFrontiers in molecular neuroscience · 2025
    Article
  13. Article
  14. Review
  15. Investigations on the Ability of the Insular Cortex to Process Peripheral Immunosuppression.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marianna K KeaveneyDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
Bahar RahseparDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.ORCID 0000-0002-8517-0177
Hua-An TsengDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
Fernando R FernandezDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.ORCID 0000-0001-9308-3594
Rebecca A MountDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
Tina TaDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.
John A WhiteDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215.ORCID 0000-0003-1073-2638
Jim BergAllen Institute for Brain Science, Seattle, Washington 98109.
Xue HanDepartment of Biomedical Engineering, Boston University, Boston, Massachusetts 02215 xuehan@bu.edu.
Boston University · USAllen Institute for Brain Science · US

Funding

Light-Actuatable NanoRobots for Molecular UncagingDP2NS082126 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HAN, XUE · 2012 to 2017
$2.9M
Causal Analysis of Electrically Connected Neural NetworksR01NS087950 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI HAN, XUE · 2013 to 2016
$1.3M
Development of microRNA-guided neuron tags (mAGNETs) to target and classify neural subtypes in the living brainF31NS095465 · NINDS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KEAVENEY (SAYEG), MARIANNA KATHERINE · 2016 to 2017
$63k
NINDS NIH HHS DP2 NS082126NINDS NIH HHS F31 NS095465NINDS NIH HHS R01 NS087950
6 · The paper itself

Abstract

Single-cell analysis is revealing increasing diversity in gene expression profiles among brain cells. Traditional promotor-based viral gene expression techniques, however, cannot capture the growing variety among single cells. We demonstrate a novel viral gene expression strategy to target cells with specific miRNA expression using miRNA-guided neuron tags (mAGNET). We designed mAGNET viral vectors containing a CaMKIIα promoter and microRNA-128 (miR-128) binding sites, and labeled CaMKIIα

Indexed as

Gene TargetingAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 2FemaleGenetic VectorsInterneuronsMaleMiceMicroRNAsMotor CortexCalcium-Calmodulin-Dependent Protein Kinase Type 2MicroRNAscalcium/calmodulin kinase type IIcell type classificationGCaMP6optogenetics

Identifiers

PMID33158963
PMCPMC7726537
OpenAlexW3097377195

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.