ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Hippocampal Theta Oscillations Support Successful Associative Memory Formation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 93 citations in OpenAlex.
- Task-Specific Personalized Theta tACS Modulates Theta Dynamics in Associative Memory.Brain and behavior · 2026Trial
- Article
- Impaired behavioral inhibition in Fmr1 KO mice is linked to disrupted visual cortex theta oscillations.Cell reports · 2026Article
- The genetic signature of memory encoding along the human hippocampal axis.bioRxiv : the preprint server for biology · 2026Article
- Chronic stress alters neurotransmitter co-expression and disrupts context discrimination in a sex-dependent manner.IBRO neuroscience reports · 2026Article
- Opposing effects of slow and fast theta synchrony on working memory in the human hippocampal-orbitofrontal network.bioRxiv : the preprint server for biology · 2026Article
- From brain waves to heartbeats: Exploring the combined role of electroencephalography and heart-rate variability in Alzheimer's disease diagnosis and management.Journal of Alzheimer's disease : JAD · 2026Review
- Micro-Stimulation Timing Framed Around an Averaged Theta Period of Stimulation Determines Hippocampal Recruitment in Cued Fear Conditioning.Hippocampus · 2026Article
- Episodic memory encoding fluctuates at a theta rhythm of 3-10 Hz.Nature human behaviour · 2026Article
- Short-term neurovascular and electrophysiological responses to combined visual and vibration stimulation in older adults with mild cognitive impairment.Frontiers in aging neuroscience · 2026Article
- Review
- Precise temporal dynamics of ripple events support order memory in human hippocampal-cortical circuits.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Prediction Error-Related Memory Enhancement Depends on the Neural State Surrounding the Prediction Error Event.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Theta-phase locking of single neurons during human spatial memory.Nature communications · 2025Article
- Neurophysiological evidence of human hippocampal longitudinal differentiation in associative memory.Nature communications · 2025Article
- Brain mechanisms underlying the inhibitory control of thought.Nature reviews. Neuroscience · 2025Review
- Models of human hippocampal specialization: a look at the electrophysiological evidence.Trends in cognitive sciences · 2025Review
- Neurite development varies across the hippocampus and covaries with the cellular composition of hippocampal tissue.Communications biology · 2025Article
- CHOLINERGIC MODULATION OF CELLULAR RESONANCE IN NON-HUMAN PRIMATE HIPPOCAMPUS.bioRxiv : the preprint server for biology · 2025Article
- Utilizing tACS to enhance memory confidence and EEG to predict individual differences in brain stimulation efficacy.Imaging neuroscience (Cambridge, Mass.) · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
Models of memory formation posit that episodic memory formation depends critically on the hippocampus, which binds features of an event to its context. For this reason, the contrast between study items that are later recollected with their associative pair versus those for which no association is made fails should reveal electrophysiological patterns in the hippocampus selectively involved in associative memory encoding. Extensive data from studies in rodents support a model in which theta oscillations fulfill this role, but results in humans have not been as clear. Here, we used an associative recognition memory procedure to identify hippocampal correlates of successful associative memory encoding and retrieval in patients (10 females and 9 males) undergoing intracranial EEG monitoring. We identified a dissociation between 2-5 Hz and 5-9 Hz theta oscillations, by which power increases in 2-5 Hz oscillations were uniquely linked with successful associative memory in both the anterior and posterior hippocampus. These oscillations exhibited a significant phase reset that also predicted successful associative encoding and distinguished recollected from nonrecollected items at retrieval, as well as contributing to relatively greater reinstatement of encoding-related patterns for recollected versus nonrecollected items. Our results provide direct electrophysiological evidence that 2-5 Hz hippocampal theta oscillations preferentially support the formation of associative memories, although we also observed memory-related effects in the 5-9 Hz frequency range using measures such as phase reset and reinstatement of oscillatory activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.