ArticleCancer discovery2021
Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer.
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Article in Cancer discovery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
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Who cites it
93 citing papers in PubMed, 131 citations in OpenAlex.
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- CAF-derived PAI-1 serves as an EGFR ligand and fuels KRAS-mutant pancreatic cancer.Nature communications · 2026Article
- KMT2D depletion promotes KRAS-induced pancreatic carcinogenesis independent of TP53.The Journal of biological chemistry · 2026Article
- Engineered Cell Membrane-Coated Nanoparticles: A New Strategy for Pancreatic Cancer Therapy.ACS pharmacology & translational science · 2026Review
- Epigenetic modulation to overcome immune suppression in pancreatic cancer.Clinical epigenetics · 2026Review
- Targeting MDSCs in cancer: emerging immunotherapeutic and metabolic strategies.Frontiers in immunology · 2026Review
- Pancreatic cancer immunotherapy biomarkers: from traditional markers to multimodal integration and dynamic monitoring.Frontiers in immunology · 2026Review
- High-throughput screening to engineer optimal T cell therapies: current knowledge and future prospects.Frontiers in oncology · 2026Review
- KDM3A drives NSCLC proliferation and metastasis via H3K9 demethylation, EMT activation and MMP-9 upregulation.Biomolecules & biomedicine · 2025Article
- Methods and applications of in vivo CRISPR screening.Nature reviews. Genetics · 2025Review
- CRISPR/Cas technologies in pancreatic cancer research and therapeutics: recent advances and future outlook.Discover oncology · 2025Review
- Integrative bioinformatics analysis identifies METTL1 as a regulator of immune infiltration and prognosis in breast cancer.Scientific reports · 2025Article
- Perturbomics: CRISPR-Cas screening-based functional genomics approach for drug target discovery.Experimental & molecular medicine · 2025Review
- Dynamic variations in peripheral blood indices and their association with efficacy and adverse reactions of pd- 1 inhibitor combined chemotherapy in patients with advanced gastric cancer.BMC gastroenterology · 2025Article
- ABCF1-K430-Lactylation promotes HCC malignant progression via transcriptional activation of HIF1 signaling pathway.Cell death and differentiation · 2025Article
- Finding a needle in a haystack: functional screening for novel targets in cancer immunology and immunotherapies.Oncogene · 2025Review
- Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells.Cell death & disease · 2025Article
- Predictive value of dendritic cell-related genes for prognosis and immunotherapy response in lung adenocarcinoma.Cancer cell international · 2025Article
- Integrative Analysis of eQTL Genes Reveals Key Biomarkers and Mechanisms for Early Diagnosis of Pancreatic Ductal Adenocarcinoma.Cancer informatics · 2025Article
33 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 4 institutions in 1 country.
Jinyang Li *Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0001-8125-6603
Salina Yuan *Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-7503-7081
Robert J NorgardDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Fangxue YanDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-3107-426X
Yu H SunCenter for RNA Biology, Department of Biochemistry and Biophysics, Department of Biology, University of Rochester Medical Center, Rochester, New York.
Il-Kyu KimDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Allyson J MerrellDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Yogev SelaDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Yanqing JiangDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Natarajan V BhanuPenn Epigenetics Institute, University of Pennsylvania, Philadelphia, Pennsylvania.
Benjamin A GarciaPenn Epigenetics Institute, University of Pennsylvania, Philadelphia, Pennsylvania.
Robert H VonderheideDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID 0000-0002-7252-954X
Andrés BlancoDepartment of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Ben Z StangerDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. bstanger@upenn.edu.ORCID 0000-0003-0410-4037
Cancer Research Institute · USScience History Institute · USUniversity of Pennsylvania · USUniversity of Rochester Medical Center · US
Funding
Shared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI YOUNG, MICHAEL WARREN · 2015 to 2024
$17.6MUnderstanding and Overcoming Resistance to Immunotherapies in Childhood CancersU54CA232568 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI MACKALL, CRYSTAL, MARIS, JOHN M · 2018 to 2022
$13.1MViral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4MMechanisms of bile duct reprogrammingR01DK083355 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI GROMPE, MARKUS, STANGER, BEN Z · 2009 to 2020
$4.3MMolecular Determinants and Therapeutic Consequences of Immune Heterogeneity in CancerR01CA229803 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STANGER, BEN Z, VONDERHEIDE, ROBERT H · 2018 to 2022
$3.7MImmunobiology and immunotherapy of pancreatic cancerR01CA169123 · NCI · UNIVERSITY OF PENNSYLVANIA · PI STANGER, BEN Z, VONDERHEIDE, ROBERT H · 2012 to 2016
$3.1MInvestigating the role of C1-INH in pancreatic ductal adenocarcinoma progressionF30CA224970 · NCI · UNIVERSITY OF PENNSYLVANIA · PI YUAN, SALINA · 2018 to 2020
$114kNCI NIH HHS F30 CA224970NCI NIH HHS P01 CA196539NCI NIH HHS R01 CA169123NCI NIH HHS R01 CA229803NCI NIH HHS U54 CA232568NIAID NIH HHS R01 AI118891NIDDK NIH HHS R01 DK083355
Abstract
Although immunotherapy has revolutionized cancer care, patients with pancreatic ductal adenocarcinoma (PDA) rarely respond to these treatments, a failure that is attributed to poor infiltration and activation of T cells in the tumor microenvironment (TME). We performed an
Indexed as
Epigenesis, GeneticGene Expression Regulation, NeoplasticAnimalsBiomarkers, TumorCell Line, TumorCombined Modality TherapyCRISPR-Cas SystemsErbB ReceptorsGenomicsHumansImmunityJumonji Domain-Containing Histone DemethylasesLymphocytes, Tumor-InfiltratingMiceMutationPancreatic NeoplasmsBiomarkers, TumorEGFR protein, humanErbB ReceptorsJumonji Domain-Containing Histone DemethylasesKDM3A protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.