Evidence map›Paper›PMID 33158820›Full record

ArticleBMJ open2020

Association between platelet count and hepatocellular carcinoma overall survival: a large retrospective cohort study.

Linbin Lu, Zhimin Su, Peichan Zheng, Zhixian Wu, Yan Zhang, Huimin He, Jingnan Liu, Shan Lin, Xiong Chen

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PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Linbin Lu *Department of Oncology, 900th Hospital of PLA, Fuzhou, China.
Zhimin Su *Department of Medical Oncology, Xiamen Branch, Zhongshan Hospital, Fudan University, Shanghai, China.
Peichan Zheng *Fujian Center for Safety Evaluation of New Drug, Fujian Medical University, Fuzhou, China.
Zhixian Wu *Department of Hepatobiliary Disease, 900th Hospital of PLA, Fuzhou, China.
Yan ZhangDepartment of Oncology, 900th Hospital of PLA, Fuzhou, China.
Huimin HeDepartment of Oncology, 900th Hospital of PLA, Fuzhou, China.
Jingnan LiuDepartment of Oncology, 900th Hospital of PLA, Fuzhou, China.
Shan LinDepartment of Neurology, 900th Hospital of PLA, Fuzhou, China.
Xiong ChenDepartment of Oncology, 900th Hospital of PLA, Fuzhou, China cxiongzpc@fjmu.edu.cn.ORCID 0000-0001-5316-6512

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo explore the non-linear relationship between platelet count (PLT) and hepatocellular carcinoma (HCC) overall survival (OS).

settingThe study was done in Sun Yat-sen University Cancer Center (SYSUCC) from January 2007 to May 2012, a total of 5005 consecutive participants at SYSUCC were retrospectively reviewed, and 979 patients with Barcelona clinic liver cancer (BCLC) stage B were selected for the final analysis.

participantsA total of 979 newly diagnosed patients with HCC with BCLC stage B were identified for the secondary analysis. Eight cases were excluded for missing data of PLT.

main outcome measuresCox proportional hazard regression models were used to calculate multivariable-adjusted HRs and 95% CIs for HCC. The non-linear relationship was estimated through a restricted cubic spline regression, and a two-piecewise Cox proportional hazards model was further performed to calculate the threshold effect. We used multiple imputation to deal with the missing data.

resultsIn the multivariate analysis, Log PLT was associated with a 91% risk increase in death (HR 1.91; 1.28 to 2.85) with adjustment for gender, Child-Pugh class, age × diameter of main tumour, both lobe with lesions × number of the intrahepatic lesions, alpha-fetoprotein (<25, ≥25) and lactic dehydrogenase (<245, ≥245). We also found a U-shape relationship between PLT and HCC OS at the inflexion point of 67.6×10

conclusionPLT was nonlinearly associated with HCC OS.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsFemaleHumansMaleMiddle AgedNeoplasm StagingPlatelet CountProportional Hazards ModelsRetrospective Studiesgastroenterologyhepatobiliary tumoursoncogenes

Identifiers

PMID33158820
PMCPMC7651714

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.