Evidence map›Paper›PMID 33158806›Full record

ReviewJournal of infection and public health2020

Case report of a neonate with high viral SARSCoV-2 loads and long-term virus shedding.

Monique A L J Slaats, Maud Versteylen, Karin B Gast, Bas B Oude Munnink, Suzan D Pas, Robbert G Bentvelsen, Ron van Beek

Open access · goldAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of infection and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 3 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Monique A L J SlaatsDepartment of Pediatrics, Amphia Hospital, Molengracht 21, 4818 CK, Breda, The Netherlands. Electronic address: moniqueslaats@gmail.com.
Maud VersteylenDepartment of Pediatrics, Amphia Hospital, Molengracht 21, 4818 CK, Breda, The Netherlands.
Karin B GastMicrovida, Location Amphia, Molengracht 21, 4818 CK, Breda, The Netherlands.
Bas B Oude MunninkDepartment of Viroscience, WHO Collaborating Centre for Arbovirus and Viral Hemorrhagic Fever Reference and Research, Erasmus University Medical Center, Molewaterplein 50, 3015 CE, Rotterdam, The Netherlands.
Suzan D PasMicrovida, Location Amphia, Molengracht 21, 4818 CK, Breda, The Netherlands.
Robbert G BentvelsenMicrovida, Location Amphia, Molengracht 21, 4818 CK, Breda, The Netherlands.
Ron van BeekDepartment of Pediatrics, Amphia Hospital, Molengracht 21, 4818 CK, Breda, The Netherlands.
Amphia Ziekenhuis · NLErasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSARS-CoV-2 has spread globally. Currently, literature of SARS-CoV-2 in neonates is scarce. We present a case of a neonate with a high viral load and prolonged virus shedding.

methodsEpidemiology, clinical characteristics, treatment, laboratory data and follow-up information and the treatment of a neonate with COVID-19 were recorded.

resultsA 7-day-old boy was admitted to the hospital with fever, lethargy and apnoea. He was found SARS-CoV-2 RNA positive with an exceptionally high viral load in nasopharyngeal swab and stool. The father and two maternity nurses at home had detectable SARS-CoV-2 RNA as well. Sequencing showed all strains belonged to the same cluster. The father was asymptomatic and the maternity nurses developed symptoms after visiting. In the mother, no SARS-CoV-2 RNA could be found. Six days after admission, the neonate was discharged after clinical improvement with oral antibiotics because of a possible pyelonephritis. Monitoring the course of this infection showed that SARS-CoV-2 RNA was detectable in the nasopharynx until day 19 and in stool until day 42 after symptom onset.

conclusionsThis case shows that neonates can have a high viral load of SARS-CoV-2 and can shed the virus for over one month in stool. Despite the high viral load in the neonate, the mother and a sibling did not get infected.

Indexed as

SARS-CoV-2COVID-19Diagnosis, DifferentialFeverHumansInfant, NewbornMaleViral LoadVirus SheddingCOVID19NeonatesNovel coronavirusSARS-CoV-2

Identifiers

PMID33158806
PMCPMC7590917
OpenAlexW3097336038

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.