ArticleSeminars in cell & developmental biology2021
The adverse impact of cadmium on immune function and lung host defense.
Article in Seminars in cell & developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 68 citations in OpenAlex.
- Multi-Targeted Mechanisms of Phytochemicals in Mitigating Cadmium-Induced Breast Cancer.Medicines (Basel, Switzerland) · 2026Review
- Evaluation of the effects of exposure to heavy metals in rescue dogs and their role as environmental biomonitors after the Brumadinho disaster, Minas Gerais, Brazil.One health (Amsterdam, Netherlands) · 2025Article
- Association between heavy metal exposure and chronic cough: the mediating roles of inflammation.Annals of medicine · 2025Article
- Association of Different Doses and Routes of Acute Cadmium Exposure With Bone Marrow Hypoplasia, Cellular and Biochemical Alterations in Male Wistar Rats.Biological trace element research · 2025Article
- Associations of cadmium exposure within heavy metal combinations with osteoporosis risk: an analysis of NHANES data (2013-2014 and 2017-2018).Aging clinical and experimental research · 2025Article
- Systemic inflammation mediates the relationship between urinary cadmium and chronic cough risk: findings based on multiple statistical models.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Mitigating Cadmium Toxicity: Role of Caffeine in the Reduction of Oxidative Stress.Open veterinary journal · 2025Article
- Heavy Metal Contamination: Sources, Health Impacts, and Sustainable Mitigation Strategies with Insights from Nigerian Case Studies.F1000Research · 2025Review
- Determining the Feasibility of a Cadmium Exposure Model to Activate the Inflammatory Arm of PANoptosis in Murine Monocytes.International journal of molecular sciences · 2024Article
- Blood cadmium concentration and pulmonary function injury: potential mediating role of oxidative stress in chronic obstructive pulmonary disease patients.BMC pulmonary medicine · 2024Article
- Urinary cadmium was linearly and positively associated with cardiac infarction/injury score and subclinical myocardial injury in the general population without cardiovascular diseases and chronic kidney disease.International urology and nephrology · 2024Article
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- The Correlation between Metal Mixed Exposure and Lung Function in Different Ages of the Population.Metabolites · 2024Article
- Association of blood cadmium concentration with chronic obstructive pulmonary disease progression: a prospective cohort study.Respiratory research · 2024Article
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- Heavy metal levels and flavonoid intakes are associated with chronic obstructive pulmonary disease: an NHANES analysis (2007-2010 to 2017-2018).BMC public health · 2023Article
- Associations between environmental heavy metals exposure and preserved ratio impaired spirometry in the U.S. adults.Environmental science and pollution research international · 2023Article
- Heavy metals in unrecorded Albanian rakia: A pilot study on a potential public health risk.Heliyon · 2023Article
- The Cd/Zn Axis: Emerging Concepts in Cellular Fate and Cytotoxicity.Biomolecules · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cadmium (Cd) is a transition metal, also referred to as a heavy metal, that is naturally abundant in the earth's crust. It has no known benefit to humans. It is primarily released into our environment through mining and smelting in industrial processes and enters the food chain through uptake by plants from contaminated soil and water. In humans, Cd primarily enters the body through ingestion of foods and cigarette smoke and has an extremely long resident half-life in the body compared to other transition metals. Environmental workplace exposure is also a source through inhalation, although much less common. The principal organs adversely affected by Cd following acute and chronic exposure are the kidneys, bone, vasculature and lung. Cd adversely impacts cell function through changes in gene expression and signal transduction and is recognized as a carcinogen. Despite a substantial body of mechanistic studies in cells and animal models, the overall impact of Cd on innate immune function in humans remains poorly understood. The best evidence is perhaps alteration of reactive oxygen species balance and signaling in cells that regulate innate immunity causing alteration of the inflammatory response that is postulated to contribute to chronic diseases. Epidemiologic studies support this possibility since increased tissue levels in humans are strongly associated with leading chronic diseases including chronic obstructive pulmonary disease (COPD), which will be discussed in depth. Additional studies are required to understand how chronic exposure and accumulation of this leading environmental toxicant in vital organs negatively impact innate immune function and host defense leading to chronic disease in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.