Evidence map›Paper›PMID 33158499›Full record

Observational studyBritish journal of anaesthesia2021

Postoperative troponin increases after noncardiac surgery are associated with raised neurofilament light: a prospective observational cohort study.

Robert D Sanders, Lenka Craigova, Benjamin Schessler, Cameron Casey, Marissa White, Margaret Parker, David Kunkel, Kaj Blennow, Henrik Zetterberg, Robert A Pearce and 1 more

2 registry-linked trialsOpen access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in British journal of anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02926417 completednot on this map

Interventions for Postoperative Delirium: Biomarker-2 (IPOD-B2) Pilot Study

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2016 to 2019Enrolled32ConditionsDeliriumArmsHigh Density-Electroencephalogram
NCT03124303 recruitingnot on this map

Interventions for Postoperative Delirium: Biomarker-3

TypeobservationalSponsorUniversity of Wisconsin, MadisonRan2017 to 2029Enrolled468ConditionsDeliriumArmsHigh Density-Electroencephalogram, Magnetic Resonance Imaging, Blood specimen collection, Pupillometry
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Reduced Electroencephalogram Complexity in Postoperative Delirium.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  9. Article
  10. Mechanisms of Post-critical Illness Cardiovascular Disease.Frontiers in cardiovascular medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 4 countries.

Robert D SandersUniversity of Sydney, Sydney, NSW, Australia; Department of Anaesthetics, Royal Prince Alfred Hospital, Camperdown, NSW, Australia; Institute of Academic Surgery, Royal Prince Alfred Hospital, Camperdown, NSW, Australia. Electronic address: robert.sanders@sydney.edu.au.
Lenka CraigovaMedical Student Training Program, University of Wisconsin, Madison, WI, USA.
Benjamin SchesslerDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Cameron CaseyDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Marissa WhiteDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Margaret ParkerDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
David KunkelDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Henrik ZetterbergClinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK; UK Dementia Research Institute at UCL, London, UK.
Robert A PearceDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
Richard LennertzDepartment of Anesthesiology, University of Wisconsin, Madison, WI, USA.
University of Wisconsin–Madison · USSahlgrenska University Hospital · SEThe University of Sydney · AU

Funding

Clarifying the overlapping pathology of delirium and dementiaR01AG063849 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Richard C Lennertz, Robert D Sanders · 2019 to 2026
$5.0M
The Cognitive Disintegration Model of Delirium: A Clinical Cohort Study Investigating Neural Network Connectivity and Local Slow Wave ActivityK23AG055700 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SANDERS, ROBERT D · 2018 to 2020
$483k
NIA NIH HHS K23 AG055700NIA NIH HHS R01 AG063849
6 · The paper itself

Abstract

backgroundMyocardial and neuronal injury occur commonly after noncardiac surgery. We examined whether patients who had perioperative myocardial injury (PMI) also incurred neuronal injury, and whether myocardial and neuronal injury were associated with similar changes in inflammatory markers or overlapping clinical predictors.

methodsA total of 114 individuals >65 yr old were recruited from two ongoing perioperative cohort studies (NCT02926417; NCT03124303). Plasma samples were collected before and daily after surgery to process assays for troponin I (PMI), neurofilament light (NfL; neuronal injury) and multiplexed plasma cytokines (inflammation). The primary outcome was the change in NfL in individuals with PMI (>40 pg ml

resultsNinety-six patients had paired NfL and troponin data. Twenty-three of 94 subjects (24%) with PMI had greater increases in NfL (median [inter-quartile range, IQR]: 29 pg ml

conclusionsPostoperative troponin increases were associated with changes in NfL and inflammatory cytokines. Increases in troponin, but not NfL, were associated with intraoperative hypotension, suggesting differences in the mechanisms contributing to neuronal and myocardial injury.

Indexed as

AgedBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedNeurofilament ProteinsPostoperative ComplicationsProspective StudiesTroponin IBiomarkersneurofilament protein LNeurofilament ProteinsTroponin Ideliriuminflammationinjurymyocardialneuronalsurgerytroponin

Identifiers

PMID33158499
PMCPMC8176651
OpenAlexW3096593121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.