Evidence map›Paper›PMID 33158488›Full record

ArticleMaturitas2020

Anticholinergic medication exposure predicts poor physical capability: Findings from a large prospective cohort study in England.

Kaisa R Yrjana, Victoria L Keevil, Roy L Soiza, Robert N Luben, Nicholas J Wareham, Kay-Tee Khaw, Phyo K Myint

Abstract read
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In one paragraph

Article in Maturitas, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Health-related quality of life and use of medication with anticholinergic activity in patients with multiple myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Article
  5. Article
  6. Anticholinergic Medication Use, Dopaminergic Genotype, and Recurrent Falls.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022
    Article
  7. Polypharmacy Results in Functional Impairment in Mice: Novel Insights Into Age and Sex Interactions.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaisa R YrjanaAgeing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK; Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Victoria L KeevilDepartment of Medicine for the Elderly, Addenbrooke's Hospital, Cambridge, UK; Cambridge Institute of Public Health, University of Cambridge, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK.
Roy L SoizaAgeing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK; Department of Medicine for the Elderly, Aberdeen Royal Infirmary, Aberdeen, UK.
Robert N LubenDepartment of Public Health & Primary Care University of Cambridge, Cambridge, UK.
Nicholas J WarehamMedical Research Council Epidemiology Unit, University of Cambridge, Cambridge, UK.
Kay-Tee KhawDepartment of Public Health & Primary Care University of Cambridge, Cambridge, UK.
Phyo K MyintAgeing Clinical & Experimental Research (ACER) Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK; Department of Medicine for the Elderly, Aberdeen Royal Infirmary, Aberdeen, UK. Electronic address: phyo.myint@abdn.ac.uk.

Funding

Cancer Research UK 14136Medical Research Council G0401527Medical Research Council G0500300Medical Research Council G1000143Medical Research Council MC_UU_00006/1Medical Research Council MC_UU_12015/1Medical Research Council MR/N003284/1Medical Research Council MR/T023902/1
6 · The paper itself

Abstract

objectivesTo examine whether anticholinergic medication exposure in middle and late life is associated with physical capability. STUDY

designWe used data from 8477 men and women who had enrolled in the European Prospective Investigation of Cancer-Norfolk study at baseline (1HC; 1993-1997) and who had attended its third health examination (3HC; 2004-2010). Medication history at the 1HC and 3HC was used to score participants according to the Anticholinergic Cognitive Burden (ACB) Scale at baseline and 3HC; participants were categorised as ACB = 0, ACB = 1, ACB>2.

main outcome measureAt 3HC, physical capability was objectively measured by: usual walking speed, maximum grip strength, timed chair stands speed (TCSS) and standing balance. Linear and logistic regression models examined prospective and cross-sectional associations between ACB and physical capability, controlling for co-morbidity, sociodemographic and lifestyle factors.

resultsThe analyses included 3386 men and 4110 women who were 56.4 (SD 7.9) and 55.0 (7.7) years old respectively at baseline and 69.4 (8.1) and 67.9 (8.0) years old at follow-up. Significant cross-sectional and prospective relationships were observed for all physical capability measures in women, except grip strength. For example, women with ACB ≥ 2 compared with ACB = 0 at baseline had 0.07 m/s (95 % CI -0.11, -0.03) slower usual walking speed, 2.61 stands/min (-4.17, -1.05) slower TCSS and higher odds of being unable to complete a tandem stand (odds ratio 2.40, 95 % CI 1.53, 3.76). These trends were observed in men but were less consistent in prospective analyses.

conclusionExposure to anticholinergic medication predicts poor physical capability and is a potentially reversible risk factor.

Indexed as

Physical FitnessAgedAged, 80 and overCholinergic AntagonistsCross-Sectional StudiesEnglandFemaleHand StrengthHumansMaleMiddle AgedPostural BalanceProspective StudiesRisk FactorsTime and Motion StudiesWalking SpeedCholinergic AntagonistsAnticholinergic burdenOlder peoplePhysical capability

Identifiers

PMID33158488
PMCPMC7656240

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.