Evidence map›Paper›PMID 33158258›Full record

ArticleCancers2020

Prognostic Role of the Red Blood Cell Distribution Width (RDW) in Hodgkin Lymphoma.

Ines Herraez, Leyre Bento, Raquel Del Campo, Adriana Sas, Rafael Ramos, Javier Ibarra, Francesc Mestre, Regina Alemany, Joan Bargay, Antonia Sampol and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  15. Risk Prediction for Rapidly Progressive Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis: The CRAFT Model.Medical science monitor : international medical journal of experimental and clinical research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Ines HerraezDepartment of Hematology, Son Llatzer University Hospital, 07198 Palma de Mallorca, Spain.ORCID 0000-0003-1061-9889
Leyre BentoHealth Research Institute of the Balearic Islands (IdISBa-IUNICS), 07120 Palma de Mallorca, Spain.
Raquel Del CampoDepartment of Hematology, Son Llatzer University Hospital, 07198 Palma de Mallorca, Spain.
Adriana SasHealth Research Institute of the Balearic Islands (IdISBa-IUNICS), 07120 Palma de Mallorca, Spain.
Rafael RamosHealth Research Institute of the Balearic Islands (IdISBa-IUNICS), 07120 Palma de Mallorca, Spain.
Javier IbarraHealth Research Institute of the Balearic Islands (IdISBa-IUNICS), 07120 Palma de Mallorca, Spain.
Francesc MestreHealth Research Institute of the Balearic Islands (IdISBa-IUNICS), 07120 Palma de Mallorca, Spain.
Regina AlemanyHealth Research Institute of the Balearic Islands (IdISBa-IUNICS), 07120 Palma de Mallorca, Spain.
Joan BargayDepartment of Hematology, Son Llatzer University Hospital, 07198 Palma de Mallorca, Spain.
Antonia SampolHealth Research Institute of the Balearic Islands (IdISBa-IUNICS), 07120 Palma de Mallorca, Spain.
Antonio GutierrezHealth Research Institute of the Balearic Islands (IdISBa-IUNICS), 07120 Palma de Mallorca, Spain.ORCID 0000-0001-9062-077X
Health Research Institute of the Balearic Islands · ESHospital Son Llatzer · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The red blood cell distribution width (RDW) is a parameter available from an automated blood count, which measures the degree of heterogeneity of erythrocyte volume and increases in inflammatory conditions. The prognostic role of RDW has been described in different types of cancers. Hodgkin lymphoma (HL) is a hematological malignancy, known to have a proinflammatory background. We aim to study the prognostic role of RDW in HL. We retrospectively analyzed 264 patients with HL from two hospitals in the Balearic Islands between 1990 and 2018. Higher levels of RDW were independently related to anemia, B-symptoms, and low albumin. In age ≥45 years, the presence of lymphopenia and higher RDW were independently associated with worse event-free survival (EFS) and overall survival (OS). Long-term incidence of secondary malignancies was significantly higher in patients with higher RDW, particularly lung cancer. In conclusion, we report for the first time that RDW is a simple, cheap, and easily available prognostic factor in HL that identifies a group with worse EFS, OS, and a higher potential incidence of secondary malignancies. RDW seems to be related to most adverse prognostic factors in HL, making RDW an excellent candidate to be included in prognostic scores for HL.

Indexed as

Hodgkin lymphomaRDWrisk factorssecondary malignanciessurvival

Identifiers

PMID33158258
PMCPMC7694294
OpenAlexW3097901160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.