Evidence map›Paper›PMID 33158254›Full record

ArticleMolecules (Basel, Switzerland)2020

(5-Hydroxy-4-oxo-2-styryl-4

Huan Chen, Xin Zhang, Xiaonan Zhang, Wenchao Liu, Yanqi Lei, Changjin Zhu, Bing Ma

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Pyridine Derivatives: A Comprehensive Review of Their Potential as Anti-Diabetic Agents.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huan ChenSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Xin ZhangSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Xiaonan ZhangSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Wenchao LiuSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Yanqi LeiSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Changjin ZhuSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.
Bing MaSchool of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, China.

Funding

National Natural Science Foundation of China 21272025
6 · The paper itself

Abstract

As rate-limited enzyme of polyol pathway, aldose reductase (ALR2) is one of the key inhibitory targets for alleviating diabetic complications. To reduce the toxic side effects of the inhibitors and to decrease the level of oxidative stress, the inhibitory selectivity towards ALR2 against detoxicating aldehyde reductase (ALR1) and antioxidant activity are included in the design of multifunctional ALR2 inhibitors. Hydroxypyridinone derivatives were designed, synthesized and evaluated their inhibitory behavior and antioxidant activity. Notably, {2-[2-(3,4-dihydroxy-phenyl)-vinyl]-5-hydroxy-4-oxo-4

Indexed as

AcetatesAldehyde ReductaseEnzyme InhibitorsMolecular Docking SimulationHumansMolecular StructureStructure-Activity RelationshipAcetatesAKR1A1 protein, humanAKR1B1 protein, humanAldehyde ReductaseEnzyme Inhibitorsaldose reductase inhibitorsantioxidant activitymolecular dockingpyridinones derivatives

Identifiers

PMID33158254
PMCPMC7663616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.