Evidence map›Paper›PMID 33158106›Full record

SynthesisCells2020

Cardiac and Vascular α

Gizem Kaykı-Mutlu, Olga Papazisi, Meindert Palmen, A H Jan Danser, Martin C Michel, Ebru Arioglu-Inan

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Observational
  3. Sympathetic Nervous System and Atherosclerosis.International journal of molecular sciences · 2023
    Review
  4. Evaluation ofToxicology reports · 2023
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Gizem Kaykı-MutluDepartment of Pharmacology, Faculty of Pharmacy, Ankara University, 06560 Ankara, Turkey.ORCID 0000-0002-3177-9438
Olga PapazisiDepartment of Cardiothoracic Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Meindert PalmenDepartment of Cardiothoracic Surgery, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
A H Jan DanserDepartment of Internal Medicine, Division of Pharmacology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-5052-3585
Martin C MichelDepartment of Pharmacology, Johannes Gutenberg University, 55131 Mainz, Germany.ORCID 0000-0003-4161-8467
Ebru Arioglu-InanDepartment of Pharmacology, Faculty of Pharmacy, Ankara University, 06560 Ankara, Turkey.
Ankara University · TRLeiden University Medical Center · NLErasmus MC · NLJohannes Gutenberg University Mainz · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As heart failure (HF) is a devastating health problem worldwide, a better understanding and the development of more effective therapeutic approaches are required. HF is characterized by sympathetic system activation which stimulates α- and β-adrenoceptors (ARs). The exposure of the cardiovascular system to the increased locally released and circulating levels of catecholamines leads to a well-described downregulation and desensitization of β-ARs. However, information on the role of α-AR is limited. We have performed a systematic literature review examining the role of both cardiac and vascular α

Indexed as

Blood VesselsHeart FailureHumansModels, BiologicalMyocardiumReceptors, Adrenergic, alpha-1Signal TransductionReceptors, Adrenergic, alpha-1blood vesselcardiomyocyteheart failureα1-adrenoceptors

Identifiers

PMID33158106
PMCPMC7694190
OpenAlexW3095928207

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.