ArticleMedicine2020
Platelets as a prognostic marker for sepsis: A cohort study from the MIMIC-III database.
Article in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- The clinical significance of thrombocytopenia in sepsis and septic shock: a systematic review and meta-analysis.BMC anesthesiology · 2025Pooled it
- Predictive Value of Platelet-Based Indexes for Mortality in Sepsis.Biomedicines · 2026Article
- An explainable prognostic prediction panel for sepsis based on serum amino acid profiles.Frontiers in immunology · 2026Article
- Group-based trajectory modeling of platelet dynamics in sepsis: from phenotypic identification to the exploration of prognostic mediators.Frontiers in medicine · 2026Article
- Prediction of 28-day mortality in patients with sepsis based on a predictive model: A retrospective cohort study.The Journal of international medical research · 2025Article
- NLR and Platelet Dynamics: Simple, Cost-effective Biomarkers for Stratifying Severity in Acute Pancreatitis.Medical journal of the Islamic Republic of Iran · 2025Article
- Prophylactic proton pump inhibitor use and all-cause mortality in adult sepsis patients: a retrospective analysis based on the MIMIC-IV database.Frontiers in pharmacology · 2025Article
- Identification of Time-Series Pattern Marker in Its Application to Mortality Analysis of Pneumonia Patients in Intensive Care Unit.Journal of personalized medicine · 2024Article
- Article
- Explainable machine learning for early prediction of sepsis in traumatic brain injury: A discovery and validation study.PloS one · 2024Article
- Association between ferritin to albumin ratio and 28-day mortality in patients with sepsis: a retrospective cohort study.European journal of medical research · 2023Article
- C-reactive protein-to-albumin ratio as a biomarker in patients with sepsis: a novel LASSO-COX based prognostic nomogram.Scientific reports · 2023Article
- Tracking longitudinal biomarkers in burn patients with sepsis and acute kidney injury: an unsupervised clustering approach.European journal of medical research · 2023Article
- Organism type of infection is associated with prognosis in sepsis: an analysis from the MIMIC-IV database.BMC infectious diseases · 2023Article
- Article
- Exploring the risk factors of early sepsis after liver transplantation: development of a novel predictive model.Frontiers in medicine · 2023Article
- UHPLC/MS-Based Serum Metabolomics Reveals the Mechanism of Radiation-Induced Thrombocytopenia in Mice.International journal of molecular sciences · 2022Article
- Hematologic System Dysregulation in Critically Ill Septic Patients with Anemia-A Retrospective Cohort Study.International journal of environmental research and public health · 2022Observational
- Emerging mechanisms of immunocoagulation in sepsis and septic shock.Trends in immunology · 2021Review
- Association Between Treatments and Short-Term Biochemical Improvements and Clinical Outcomes in Post-Severe Acute Respiratory Syndrome Coronavirus-2 Inflammatory Syndrome.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies · 2021Observational
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During sepsis, platelets dysfunction contributes to organ dysfunction. Studies on platelets dysfunction in the long-term prognosis of sepsis are lacking. The aim of this study was to assess the role of platelets in the long-term prognosis of sepsis patients.A total of 4576 sepsis patients were extracted from MIMIC III Database. Survival was analyzed by the Kaplan-Meier method. Univariate and multivariate cox analyses were performed to identify prognostic factors. Significant prognostic factors were combined to build a nomogram to predict 1 year overall survival (OS). The discriminative ability and predictive accuracy of the nomogram were evaluated using the receiver operating characteristic curve (ROC) analysis and calibration curves used for sepsis.The more abnormal the platelet level, the worse prognosis of patients. After final regression analysis, age, blood urea nitrogen, platelets, international normalized ratio, partial thromboplastin time, potassium, hemoglobin, white blood cell count, organ failures were found to be independent predictors of 1 year OS of sepsis patient and were entered into a nomogram. The nomogram showed a robust discrimination, with an area under the receiver operating characteristic curve of 0.752. The calibration curves for the probability of the prognosis of sepsis patients showed optimal agreement between the probability as predicted by the nomogram and the actual probability.Platelet was an independent prognostic predictor of 1 year OS for patients with sepsis. Platelet-related nomogram that can predict the 1 year OS of sepsis patients. It revealed optimal discrimination and calibration, indicating that the nomogram may have clinical utility.
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