Evidence map›Paper›PMID 33157313›Full record

ArticleJournal of biomedical informatics2020

Detection of calibration drift in clinical prediction models to inform model updating.

Sharon E Davis, Robert A Greevy, Thomas A Lasko, Colin G Walsh, Michael E Matheny

Abstract read
In one paragraph

Article in Journal of biomedical informatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
90citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

90 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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30 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sharon E DavisDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: sharon.e.davis@vanderbilt.edu.
Robert A GreevyDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: robert.greevy@vanderbilt.edu.
Thomas A LaskoDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: tom.lasko@vanderbilt.edu.
Colin G WalshDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: colin.walsh@vanderbilt.edu.
Michael E MathenyDepartment of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Geriatrics Research, Education, and Clinical Care, Tennessee Valley Healthcare System VA, Nashville, TN, USA. Electronic address: michael.matheny@vanderbilt.edu.

Funding

IMPROVE-AKI: A Cluster-Randomized Trial of Team-Based Coaching Interventions to IMPROVE Acute Kidney InjuryR01DK113201 · NIDDK · DARTMOUTH COLLEGE · PI Jeremiah R Brown, MICHAEL E. MATHENY · 2018 to 2026
$5.1M
Information Extraction from EMRs to Predict Readmission following Acute Myocardial InfarctionR01HL130828 · NHLBI · DARTMOUTH COLLEGE · PI BROWN, JEREMIAH R, MATHENY, MICHAEL E. · 2016 to 2019
$3.1M
NHLBI NIH HHS R01 HL130828NIDDK NIH HHS R01 DK113201
6 · The paper itself

Abstract

Model calibration, critical to the success and safety of clinical prediction models, deteriorates over time in response to the dynamic nature of clinical environments. To support informed, data-driven model updating strategies, we present and evaluate a calibration drift detection system. Methods are developed for maintaining dynamic calibration curves with optimized online stochastic gradient descent and for detecting increasing miscalibration with adaptive sliding windows. These methods are generalizable to support diverse prediction models developed using a variety of learning algorithms and customizable to address the unique needs of clinical use cases. In both simulation and case studies, our system accurately detected calibration drift. When drift is detected, our system further provides actionable alerts by including information on a window of recent data that may be appropriate for model updating. Simulations showed these windows were primarily composed of data accruing after drift onset, supporting the potential utility of the windows for model updating. By promoting model updating as calibration deteriorates rather than on pre-determined schedules, implementations of our drift detection system may minimize interim periods of insufficient model accuracy and focus analytic resources on those models most in need of attention.

Indexed as

AlgorithmsModels, StatisticalCalibrationPrognosisCalibrationDrift detectionModel updatingPredictive analytics

Identifiers

PMID33157313
PMCPMC8627243

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.