Evidence map›Paper›PMID 33157296›Full record

SynthesisInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2021

Association of schistosomiasis and HIV infections: A systematic review and meta-analysis.

Pragna Patel, Charles E Rose, Eyrun F Kjetland, Jennifer A Downs, Pamela Sabina Mbabazi, Keith Sabin, Wairimu Chege, D Heather Watts, W Evan Secor

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 4 countries.

Pragna PatelDivision of Global HIV and TB, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic address: plp3@cdc.gov.
Charles E RoseDeputy Director for Non-Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Eyrun F KjetlandNorwegian Centre for Imported and Tropical Diseases, Department of Infectious Diseases Ullevaal, Oslo University Hospital, Oslo, Norway; Discipline of Public Health, University of KwaZulu-Natal, Durban, South Africa.
Jennifer A DownsCenter for Global Health, Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
Pamela Sabina MbabaziWorld Health Organization, Department of Control of Neglected Tropical Diseases, Geneva, Switzerland.
Keith SabinUNAIDS, Geneva, Switzerland.
Wairimu ChegeNational Institutes of Health, National Institutes of Allergy and Infectious Diseases, Division of AIDS, Rockville, MD, USA.
D Heather WattsOffice of the Global AIDS Coordinator, Department of State, Washington, DC, USA.
W Evan SecorDivision of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Centers for Disease Control and Prevention · USCornell University · USJoint United Nations Programme on HIV/AIDS · CHNational Institute of Allergy and Infectious Diseases · USUnited States Department of State · USUniversity of KwaZulu-Natal · ZAWorld Health Organization · CH

Funding

Intramural CDC HHS CC999999World Health Organization 001
6 · The paper itself

Abstract

backgroundFemale genital schistosomiasis (FGS) affects up to 56 million women in sub-Saharan Africa and may increase risk of HIV infection.

methodsTo assess the association of schistosomiasis with HIV infection, peer-reviewed literature published until 31 December 2018 was examined and a pooled estimate for the odds ratio was generated using Bayesian random effects models.

resultsOf the 364 abstracts that were identified, 26 were included in the summary. Eight reported odds ratios of the association between schistosomiasis and HIV; one reported a transmission hazard ratio of 1.8 (95% CI, 1.2-2.6) among women and 1.4 (95% CI, 1.0-1.9) among men; 11 described the prevalence of schistosomiasis among HIV-positive people (range, 1.5-36.6%); and six reported the prevalence of HIV among people with schistosomiasis (range, 5.8-57.3%). Six studies were selected for quantitative analysis. The pooled estimate for the odds ratio of HIV among people with schistosomiasis was 2.3 (95% CI, 1.2-4.3).

conclusionsA significant association of schistosomiasis with HIV was found. However, a specific summary estimate for FGS could not be generated. A research agenda was provided to determine the effect of FGS on HIV infection. The WHO's policy on mass drug administration for schistosomiasis may prevent HIV.

Indexed as

Africa South of the SaharaBayes TheoremFemaleHIV InfectionsHumansMaleMass Drug AdministrationPrevalenceSchistosomiasisAssociationHIVSchistosomiasisSub-Saharan Africa

Identifiers

PMID33157296
PMCPMC8883428
OpenAlexW3095836398

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.