Evidence map›Paper›PMID 33157029›Full record

ArticleCurrent biology : CB2021

The Proteomic Landscape of Centromeric Chromatin Reveals an Essential Role for the Ctf19

Weronika E Borek, Nadine Vincenten, Eris Duro, Vasso Makrantoni, Christos Spanos, Krishna K Sarangapani, Flavia de Lima Alves, David A Kelly, Charles L Asbury, Juri Rappsilber and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Weronika E BorekThe Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK.
Nadine VincentenThe Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK.
Eris DuroThe Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK.
Vasso MakrantoniThe Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK.
Christos SpanosThe Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK.
Krishna K SarangapaniDepartment of Physiology & Biophysics, University of Washington, Seattle, WA 98195-7290, USA.
Flavia de Lima AlvesThe Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK.
David A KellyThe Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK.
Charles L AsburyDepartment of Physiology & Biophysics, University of Washington, Seattle, WA 98195-7290, USA.
Juri RappsilberThe Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK; Institute of Biotechnology, Technische Universität Berlin, Gustav-Meyer-Allee 25, 13355 Berlin, Germany.
Adele L MarstonThe Wellcome Centre for Cell Biology, Institute of Cell Biology, School of Biological Sciences, Michael Swann Building, Max Born Crescent, Edinburgh EH9 3BF, UK. Electronic address: adele.marston@ed.ac.uk.
Wellcome Centre for Cell Biology · GBUniversity of Washington · US

Funding

Reconstitution and biophysical study of chromosome segregation machineryR35GM134842 · NIGMS · UNIVERSITY OF WASHINGTON · PI Charles L Asbury · 2020 to 2026
$4.7M
Supplement to Biophysical Study of Reconstituted Kinetochore-microtubule AttachmentsR01GM079373 · NIGMS · UNIVERSITY OF WASHINGTON · PI ASBURY, CHARLES · 2006 to 2019
$4.5M
NIGMS NIH HHS R01 GM079373NIGMS NIH HHS R35 GM134842Wellcome Trust
6 · The paper itself

Abstract

Kinetochores direct chromosome segregation in mitosis and meiosis. Faithful gamete formation through meiosis requires that kinetochores take on new functions that impact homolog pairing, recombination, and the orientation of kinetochore attachment to microtubules in meiosis I. Using an unbiased proteomics pipeline, we determined the composition of centromeric chromatin and kinetochores at distinct cell-cycle stages, revealing extensive reorganization of kinetochores during meiosis. The data uncover a network of meiotic chromosome axis and recombination proteins that bind to centromeres in the absence of the microtubule-binding outer kinetochore sub-complexes during meiotic prophase. We show that the Ctf19c

Indexed as

MeiosisCentromereChromatinChromosome SegregationCytoskeletal ProteinsKinetochoresMitosisProteomicsRecombinant ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsChromatinCTF19 protein, S cerevisiaeCytoskeletal ProteinsRecombinant ProteinsSaccharomyces cerevisiae Proteinsbudding yeastCCANcentromereCtf19kinetochoremeiosismetaphase Iprophase Iproteomics

Identifiers

PMID33157029
PMCPMC7846277
OpenAlexW3097423365

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.