ArticleCurrent biology : CB2021
Oxytocin Shapes Spontaneous Activity Patterns in the Developing Visual Cortex by Activating Somatostatin Interneurons.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Beyond lactation: Central oxytocin in maternal mental health and disease.Neuroscience and biobehavioral reviews · 2026Review
- Oxytocin selectively biases sensory-prefrontal communication through network-level suppression and theta coupling.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Oxytocin attenuates fear learning via enhancing somatostatin interneuron-mediated local GABAergic inhibition in the prelimbic cortex.Science advances · 2026Article
- Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution.Angewandte Chemie (International ed. in English) · 2026Article
- Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner.Neuroscience bulletin · 2026Article
- Oxytocin modulation of the insular cortex: implications for social cognition and neurodevelopmental disorders.Frontiers in neural circuits · 2026Review
- Stress induces oxytocin-Gαi-dependent remodeling of astrocytes to shape neuronal response in the amygdala.Nature communications · 2025Article
- The interplay between functional connectivity of medial and lateral visual networks, behavioral measures, and oxytocin receptor gene polymorphism (rs2254298) in autism.European child & adolescent psychiatry · 2025Article
- Complexity of the Hypothalamic Oxytocin System and its Involvement in Brain Functions and Diseases.Neuroscience bulletin · 2025Review
- Narrative Review: A Neurobiological Perspective on Resilience in Youth.JAACAP open · 2025Review
- The dynamic relationship of brain-derived neurotrophic factor and oxytocin: Introducing the concept of neurosocial plasticity.Neuroprotection (Chichester, England) · 2025Review
- Spatiotemporal Mapping of the Oxytocin Receptor at Single-Cell Resolution in the Postnatally Developing Mouse Brain.Neuroscience bulletin · 2025Article
- Development of spontaneous and sensory evoked network activity in rodent cerebral cortexFrontiers in cellular neuroscience · 2025Review
- Chemogenetic silencing reveals presynaptic GiScience · 2024Article
- Oxytocin Protects Nigrostriatal Dopamine Signal via Activating GABAergic Circuit in the MPTP-Induced Parkinson's Disease Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Network state transitions during cortical development.Nature reviews. Neuroscience · 2024Review
- Activation of oxytocin receptors in mouse GABAergic amacrine cells modulates retinal dopaminergic signaling.BMC biology · 2022Article
- Oxytocin via oxytocin receptor excites neurons in the endopiriform nucleus of juvenile mice.Scientific reports · 2022Article
- Oxytocin-like receptor expression in evolutionarily conserved nodes of a vocal network associated with male courtship in a teleost fish.The Journal of comparative neurology · 2022Article
- Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Frontiers in neural circuits · 2022Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spontaneous network activity shapes emerging neuronal circuits during early brain development prior to sensory perception. However, how neuromodulation influences this activity is not fully understood. Here, we report that the neuromodulator oxytocin differentially shapes spontaneous activity patterns across sensory cortices. In vivo, oxytocin strongly decreased the frequency and pairwise correlations of spontaneous activity events in the primary visual cortex (V1), but it did not affect the frequency of spontaneous network events in the somatosensory cortex (S1). Patch-clamp recordings in slices and RNAscope showed that oxytocin affects S1 excitatory and inhibitory neurons similarly, whereas in V1, oxytocin targets only inhibitory neurons. Somatostatin-positive (SST
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.