Evidence map›Paper›PMID 33157012›Full record

ArticleMolecular cell2020

A "Sugar-Coated" Proton Pump Comes into Focus: High-Resolution Structure of a Human V-ATPase.

Rebecca A Oot, Stephan Wilkens

Abstract readComment
PubMed Publisher
In one paragraph

Article in Molecular cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Rebecca A OotSUNY Upstate Medical University, Department of Biochemistry and Molecular Biology, Syracuse, NY 13210, USA. Electronic address: ootr@upstate.edu.
Stephan WilkensSUNY Upstate Medical University, Department of Biochemistry and Molecular Biology, Syracuse, NY 13210, USA. Electronic address: wilkenss@upstate.edu.

Funding

STRUCTURE OF THE VACUOLAR ATPASE BY ELECTRON MICROSCOPYR01GM058600 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI WILKENS, STEPHAN · 1999 to 2020
$4.8M
Structure and Regulatory Mechanisms of the Vacuolar ATPaseR35GM141908 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI WILKENS, STEPHAN · 2021 to 2025
$2.1M
A novel tool for organelle and isoform specific targeting of V-ATPase in cancerR21CA228340 · NCI · UPSTATE MEDICAL UNIVERSITY · PI WILKENS, STEPHAN · 2019 to 2020
$388k
NCI NIH HHS R21 CA228340NIGMS NIH HHS R01 GM058600NIGMS NIH HHS R35 GM141908
6 · The paper itself

Abstract

In this issue of Molecular Cell, Wang et al. (2020a) present near-atomic resolution cryoEM structures of a proton-pumping vacuolar ATPase from human cells, illuminating the glycosylation of integral subunits and identifying a novel and conserved glycolipid ligand.

Indexed as

SugarsVacuolar Proton-Translocating ATPasesCryoelectron MicroscopyHumansSugarsVacuolar Proton-Translocating ATPases

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.