ArticleIEEE transactions on medical imaging2021
Improved Color Doppler for Cerebral Blood Flow Axial Velocity Imaging.
Article in IEEE transactions on medical imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 19 citations in OpenAlex.
- Double-helix optical point spread function enables real-time mesoscopic 3D functional microangiography in the living mouse brain and skull.Nature communications · 2026Article
- Mapping Microvascular Flow via Radon Transform Ultrasound: Technical Advances and Pilot Application.BME frontiers · 2026Article
- Ultrasound Speckle Decorrelation Analysis-Based Velocimetry for 3D-Velocity-Components Measurement Using a 1D Transducer Array.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Time-Lagged Functional Ultrasound for Multi-Parametric Cerebral Hemodynamic Imaging.IEEE transactions on medical imaging · 2024Article
- The predictive value of deep learning-based cardiac ultrasound flow imaging for hypertrophic cardiomyopathy complicating arrhythmias.European journal of medical research · 2023Article
- Model-based optical coherence tomography angiography enables motion-insensitive vascular imaging.Biomedical optics express · 2021Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Conventional color Doppler ultrasound imaging suffers from mutual frequency cancellation when applied to quantify axial blood flow velocities in the rodent brain where inverse flows exist within an ultrasound measurement voxel. Here, we report an improved color Doppler-based functional ultrasound imaging method (iCD-fUS) for axial blood flow velocity imaging of the rodent brain. By applying a directional filter and high frequency noise thresholding, iCD-fUS is able to accurately quantify blood flow velocities within the brain as validated with the ultrasound localization microscopy velocimetry method. We show that iCD-fUS is able to image and resolve the directional axial blood flow velocity throughout the entire coronal section of the brain at a temporal frame rate of up to 10 Hz with a spatial resolution of ~100 [Formula: see text]. We further applied iCD-fUS to image the axial blood flow velocity change in response to whisker stimulation in an awake mouse, showing its potential for studying brain activation. With these capabilities, iCD-fUS provides a powerful, quantitative tool for in vivo chronic research.
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