Evidence map›Paper›PMID 33156495›Full record

ArticleMolecular imaging and biology2021

Imaging Early-Stage Metastases Using an

Christian A Mason, Lukas M Carter, Komal Mandleywala, Paula Demetrio de Souza Franca, Jan-Philip Meyer, Tanjeena Mamun, Joseph M Backer, Marina V Backer, Thomas Reiner, Jason S Lewis

Open access · greenAbstract read
In one paragraph

Article in Molecular imaging and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. First evaluation of [American journal of nuclear medicine and molecular imaging · 2025
    Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Christian A MasonDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Lukas M CarterDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Komal MandleywalaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Paula Demetrio de Souza FrancaDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Jan-Philip MeyerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Tanjeena MamunDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Joseph M BackerSibTech Inc., Brookfield, CT, 06804, USA.
Marina V BackerSibTech Inc., Brookfield, CT, 06804, USA.
Thomas ReinerDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Jason S LewisDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. Lewisj2@mskcc.org.ORCID 0000-0001-7065-4534
Memorial Sloan Kettering Cancer Center · USSibtech (United States) · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Leveraging Pb-203/212 for the Theranostic Imaging and Therapy of Prostate CancerR35CA232130 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S. · 2019 to 2025
$8.2M
Imaging VEGFR-1 in early metastatic lesionsR21CA216761 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI BACKER, JOSEPH M, LEWIS, JASON S. · 2017 to 2018
$405k
NCI NIH HHS P30 CA008748NCI NIH HHS R21 CA216761NCI NIH HHS R35 CA232130
6 · The paper itself

Abstract

purposeMetastatic breast cancer is the second leading cause of cancer-related death in women. The 5-year survival rate for metastatic breast cancer has remained near 26.9 % for over a decade. The recruitment of hematopoietic stem cells with high expression of the vascular endothelial growth factor receptor 1 (VEGFR-1) has been implicated in early stages of metastasis formation. We propose the use of an PROCEDURES: scVR1 was

resultsThe [

conclusionsThe diagnostic capabilities of the [

Indexed as

MutationNeoplasm MetastasisAnimalsBreast NeoplasmsCell Line, TumorFemaleFluorine RadioisotopesHematopoietic Stem CellsHeterocyclic Compounds, 1-RingHumansLung NeoplasmsMiceMice, Inbred BALB CNeoplasm TransplantationPositron-Emission TomographyVascular Endothelial Growth Factor A1,4,7-triazacyclononane-N,N',N''-triacetic acidFluorine-18Fluorine RadioisotopesHeterocyclic Compounds, 1-RingVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-1AutoradiographyImmunofluorescenceLung metastasisMetastatic breast cancerMetastatic nichePET imagingRadiochemistryTumor microenvironmentVEGFR-1

Identifiers

PMID33156495
PMCPMC8099920
OpenAlexW3096485301

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.