Evidence map›Paper›PMID 33156489›Full record

ArticleBreast cancer research and treatment2021

Drug use disorder and risk of incident and fatal breast cancer: a nationwide epidemiological study.

Disa Dahlman, Hedvig Magnusson, Xinjun Li, Jan Sundquist, Kristina Sundquist

Open access · hybridAbstract read
In one paragraph

Article in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 3 countries.

Disa DahlmanCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University/Region Skåne, Box 503 22, Malmö, Sweden. disa.dahlman@med.lu.se.ORCID http://orcid.org/0000-0003-0507-8758
Hedvig MagnussonCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University/Region Skåne, Box 503 22, Malmö, Sweden.
Xinjun LiCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University/Region Skåne, Box 503 22, Malmö, Sweden.
Jan SundquistCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University/Region Skåne, Box 503 22, Malmö, Sweden.
Kristina SundquistCenter for Primary Health Care Research, Department of Clinical Sciences, Lund University/Region Skåne, Box 503 22, Malmö, Sweden.
Lund University · SEShimane University · JP

Funding

Genetic, Social, and Developmental Epidemiology of Drug Use DisordersR01DA030005 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI KENNETH SEEDMAN KENDLER, JAN O SUNDQUIST · 2010 to 2026
$7.6M
Medicinska Fakulteten, Lunds Universitet ALF project grantNIDA NIH HHS R01 DA030005NIDA NIH HHS R01DA030005Vetenskapsrådet 2016-01176Vetenskapsrådet 2018-02400
6 · The paper itself

Abstract

purposeBreast cancer is one of the most common cancer forms in women and it is often detected by screening. However, women with drug use disorders (DUD) are less likely to be reached by screening programs. In this study, we aimed to investigate breast cancer incidence, mortality and stage at time of diagnosis among women with DUD compared to the general female population in Sweden.

methodsWe performed a follow-up study based on Swedish national register data for the period January 1997-December 2015. The study was based on 3,838,248 women aged 15-75 years, of whom 50,858 were registered with DUD. Adjusted hazard ratios (HRs) for incident and fatal breast cancer, and cancer stage at time of diagnosis, were calculated for women with and without DUD using Cox regression analysis.

resultsDUD was associated with incident breast cancer (HR 1.08, 95% confidence interval [CI] 1.02-1.14, p = 0.0069), fatal breast cancer (HR 1.60, 95% CI 1.42-1.82, p < 0.001), and stage IV breast cancer, i.e. metastasis at diagnosis (HR 2.06, 95% CI 1.44-2.95, p < 0.001).

conclusionsWomen with DUD were identified as a risk group for incident, fatal and metastasized breast cancer, which calls for attention from clinicians and policy makers. Cancer screening attendance and other healthcare seeking barriers are likely to affect the risk increase among women who use drugs; however, more research is needed on the underlying mechanisms.

Indexed as

Breast NeoplasmsSubstance-Related DisordersEarly Detection of CancerFemaleFollow-Up StudiesHumansIncidenceSwedenBreast cancerDrug abuseMortalitySweden

Identifiers

PMID33156489
PMCPMC7940313
OpenAlexW3095416297

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.