Evidence map›Paper›PMID 33156199›Full record

ArticleObstetrics and gynecology2020

Characteristics of Stillbirths Associated With Diabetes in a Diverse U.S. Cohort.

Jessica M Page, Amanda A Allshouse, Irina Cassimatis, Marcela C Smid, Erol Arslan, Vanessa Thorsten, Corette Parker, Michael W Varner, Donald J Dudley, George R Saade and 8 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in Obstetrics and gynecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Jessica M PageUniversity of Utah Health, Salt Lake City, Utah; Intermountain Health Care, Murray, Utah; Northwestern University, Feinberg School of Medicine, Chicago, Illinois; RTI International, Research Triangle Park, North Carolina; the University of Health Sciences, Van Training and Research Hospital, Van, Turkey; University of Virginia Healthcare, Charlottesville, Virginia; the University of Texas Medical Branch at Galveston, Galveston, Texas; Columbia University, New York, New York; the University of Texas Health Science Center at Houston, Houston, Texas; the Rollins School of Public Health, Emory University, Atlanta, Georgia; the University of Texas at Austin, Austin, Texas; the University of Texas Health Science Center at San Antonio, San Antonio, Texas; Brown University, Providence, Rhode Island; and Yale School of Medicine, New Haven, Connecticut.
Amanda A Allshouse
Irina Cassimatis
Marcela C Smid
Erol Arslan
Vanessa Thorsten
Corette Parker
Michael W Varner
Donald J Dudley
George R Saade
Robert L Goldenberg
Barbara J Stoll
Carol J Hogue
Radek Bukowski
Deborah Conway
Halit Pinar
Uma M Reddy
Robert M Silver
Island Institute · USThe University of Texas Health Science Center at San Antonio · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Stillbirth NetworkU01HD045954 · NICHD · RESEARCH TRIANGLE INSTITUTE · PI PARKER, CORETTE BREEDEN · 2003 to 2009
$8.4M
Utah Women's Reproductive Health Research Career Development ProgramK12HD085816 · NICHD · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2015 to 2024
$3.2M
Research on the Scope and Causes of Stillbirth in the USU10HD045944 · NICHD · UNIVERSITY OF UTAH · PI SILVER, ROBERT M. · 2003 to 2009
$2.7M
San Antonio Center for the Study of StillbirthU10HD045955 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DUDLEY, DONALD J · 2003 to 2009
$2.4M
Research on the Scope and Causes of Stillbirth in the USU10HD045925 · NICHD · EMORY UNIVERSITY · PI HOGUE, CAROL · 2003 to 2009
$2.3M
RESEARCH ON SCOPE &CAUSES OF STILLBIRTH IN THE USU10HD045953 · NICHD · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI COUSTAN, DONALD R · 2003 to 2009
$2.3M
Scope and Causes of StillbirthU10HD045952 · NICHD · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI SAADE, GEORGE R. · 2003 to 2009
$1.9M
NCATS NIH HHS UL1 TR001863NICHD NIH HHS K12 HD085816NICHD NIH HHS U01 HD045954NICHD NIH HHS U10 HD045925NICHD NIH HHS U10 HD045944NICHD NIH HHS U10 HD045952NICHD NIH HHS U10 HD045953NICHD NIH HHS U10 HD045955
6 · The paper itself

Abstract

objectiveTo characterize stillbirths associated with pregestational diabetes and gestational diabetes mellitus (GDM) in a large, prospective, U.S. case-control study.

methodsA secondary analysis of stillbirths among patients enrolled in a prospective; multisite; geographically, racially, and ethnically diverse case-control study in the United States was performed. Singleton gestations with complete information regarding diabetes status and with a complete postmortem evaluation were included. A standard evaluation protocol for stillbirth cases included postmortem evaluation, placental pathology, clinical testing as performed at the discretion of the health care professional, and a recommended panel of tests. A potential cause of death was assigned to stillbirth cases using a standardized classification tool. Demographic and delivery characteristics among women with pregestational diabetes and GDM were compared with characteristics of women with no diabetes in pairwise comparisons using χ or two-sample t tests as appropriate. Sensitivity analysis was performed excluding pregnancies with genetic conditions or major fetal malformations.

resultsOf 455 stillbirth cases included in the primary analysis, women with stillbirth and diabetes were more likely to be older than 35 years and have a higher body mass index. They were also more likely to have a gestational hypertensive disorder than women without diabetes (28% vs 9.1%; P<.001). Women with pregestational diabetes had more large-for-gestational-age (LGA) neonates (26% vs 3.4%; P<.001). Stillbirths occurred more often at term in women with pregestational diabetes (36%) and those with GDM (52%). Maternal medical complications, including pregestational diabetes and others, were more often identified as a probable or possible cause of death among stillbirths with maternal diabetes (43% vs 4%, P<.001) as compared with stillbirths without diabetes.

conclusionCompared with stillbirths in women with no diabetes, stillbirths among women with pregestational diabetes and GDM occur later in pregnancy and are associated with hypertensive disorders of pregnancy, maternal medical complications, and LGA.

Indexed as

AdolescentAdultCase-Control StudiesDiabetes, GestationalFemaleHumansHypertension, Pregnancy-InducedInfant, NewbornMiddle AgedPregnancyPregnancy ComplicationsPregnancy in DiabeticsPrenatal CareProspective StudiesStillbirthUnited States

Identifiers

PMID33156199
PMCPMC7680368
OpenAlexW3096631492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.