ArticleThe EMBO journal2021
A non-helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition.
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Article in The EMBO journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Integrating Free Amino Acid Profiles with Flavoromics to Characterize the Flavor Characteristics of DifferentFoods (Basel, Switzerland) · 2026Article
- A reversible allosteric inhibitor of GlyT2 for neuropathic pain without on-target side effects.Nature communications · 2026Article
- Structural basis for selective inhibition of human GABA transporter GAT3.Nature communications · 2026Article
- Transport of the abundant intestinal amino acid glutamine by the enteric pathogenMicrobiology (Reading, England) · 2026Article
- A reversible allosteric inhibitor of GlyT2 alleviates neuropathic pain without on-target side effects.bioRxiv : the preprint server for biology · 2025Article
- Structural basis of auxin binding and transport byProceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Pharmacological Mechanisms of SLC6 Neurotransmitter Transporter Inhibition.Advances in neurobiology · 2025Review
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- Alternating access of a bacterial homolog of neurotransmitter: sodium symporters determined from AlphaFold2 ensembles and DEER spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Cryo-EM structure of the dopamine transporter with a novel atypical non-competitive inhibitor bound to the orthosteric site.Journal of neurochemistry · 2024Article
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.Nature communications · 2024Article
- GABA transport cycle: beyond a GAT feeling.Nature structural & molecular biology · 2023Article
- Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.The EMBO journal · 2022Article
- Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATBBiomolecules · 2022Article
- Structure of cytosine transport protein CodB provides insight into nucleobase-cation symporter 1 mechanism.The EMBO journal · 2022Article
- Variations on a theme: crystal forms of the amino-acid transporter MhsT.Acta crystallographica. Section F, Structural biology communications · 2022Article
- Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter.The EMBO journal · 2022Article
- Review
- Structural basis for substrate specificity of heteromeric transporters of neutral amino acids.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
10 authors at 5 institutions in 4 countries.
Dorota FochtDepartment of Molecular Biology and Genetics, Danish Research Institute of Translational Neuroscience-DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, Denmark.ORCID 0000-0003-3373-7335
Caroline NeumannDepartment of Molecular Biology and Genetics, Danish Research Institute of Translational Neuroscience-DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, Denmark.ORCID 0000-0003-1574-1760
Joseph LyonsDepartment of Molecular Biology and Genetics, Danish Research Institute of Translational Neuroscience-DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, Denmark.
Ander Eguskiza BilbaoDepartment of Molecular Biology and Genetics, Danish Research Institute of Translational Neuroscience-DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, Denmark.
Rickard BlunckDepartment of Physics, Université de Montréal, Montréal, QC, Canada.
Lina MalinauskaiteDepartment of Molecular Biology and Genetics, Danish Research Institute of Translational Neuroscience-DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, Denmark.ORCID 0000-0003-3232-0415
Ilona O SchwarzDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Jonathan A JavitchDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Matthias QuickDepartment of Psychiatry, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0002-8620-827X
Poul NissenDepartment of Molecular Biology and Genetics, Danish Research Institute of Translational Neuroscience-DANDRITE, Nordic-EMBL Partnership for Molecular Medicine, Aarhus University, Aarhus C, Denmark.ORCID 0000-0003-0948-6628
Aarhus University · DKNew York Psychoanalytic Society and Institute · USColumbia University · USMRC Laboratory of Molecular Biology · GBUniversité de Montréal · CA
Funding
Synthetic Antigen Binder CoreU54GM087519 · NIGMS · UNIVERSITY OF CHICAGO · PI ZHOU, MING · 2010 to 2017
$31.9MProbing mechanisms of amphetamine action at plasma membrane and vesicular transporters in vitro and in vivoR01DA041510 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JAVITCH, JONATHAN A · 2017 to 2021
$2.7MMolecular mechanism of nucleobase/vitamin C transportersR01GM119396 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI QUICK, MATTHIAS · 2016 to 2020
$1.9MBoehringer Ingelheim Fonds (BIF) 2010Lundbeckfonden (Lundbeck Foundation) 2011-3868Lundbeckfonden (Lundbeck Foundation) 2015-2704Lundbeckfonden (Lundbeck Foundation) 2015-3225Lundbeckfonden (Lundbeck Foundation) 2016-2518NIDA NIH HHS R01 DA041510NIGMS NIH HHS R01 GM119396NIGMS NIH HHS U54 GM087519
Abstract
MhsT of Bacillus halodurans is a transporter of hydrophobic amino acids and a homologue of the eukaryotic SLC6 family of Na
Indexed as
Amino AcidsAmino Acid Transport SystemsBacillusBacterial ProteinsBinding SitesMembrane ProteinsProtein ConformationSubstrate SpecificityAmino AcidsAmino Acid Transport SystemsBacterial ProteinsMembrane Proteinsamino acids uptakeMhsTneurotransmittersodium symporterssubstrate recognitionX-ray crystallography
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.