ReviewThe journal of nutrition, health & aging2020
In the quest of a Standard Index of Intrinsic Capacity. A Critical Literature Review.
Review in The journal of nutrition, health & aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of multidomain and lifestyle interventions to support the intrinsic capacity of the older population.Frontiers in medicine · 2022Pooled it
- Impact of a nurse-led multidomain intervention on intrinsic capacity among community-dwelling older adults in China: a cluster randomized trial.BMC public health · 2025Trial
- Possible osteosarcopenia is associated with loss in intrinsic capacity and early cognitive deficits: a longitudinal study of older adults in Singapore.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Identification of pre-frail/frail older adults using the Integrated Care for Older People WHO Step1 screening tool: a cross sectional study.International journal of nursing studies advances · 2026Article
- Robustness in Older Adults: A Concept Analysis Using Rodgers' Evolutionary Approach.Nursing & health sciences · 2026Review
- Intrinsic Capacity, Polygenic Risk Score, and Risk of Glaucoma.Translational vision science & technology · 2026Article
- Intrinsic capacity and the risk of adverse health outcomes in older adults: a population-based study.BMC geriatrics · 2026Article
- Frailty and intrinsic capacity: integrating complementary concepts to promote healthy ageing and transformation of care.Age and ageing · 2026Review
- Is there agreement across diagnostic instruments in the identification of the impairment in intrinsic capacity later in life? A cross-sectional study with community-dwelling older adults.The journal of nutrition, health & aging · 2026Article
- Digital health platforms for intrinsic capacity monitoring in community-based integrated care for older adults: a scoping review.Frontiers in public health · 2026Article
- Intrinsic capacity, genetic susceptibility, and the risks of metabolic dysfunction-associated steatotic liver disease and cirrhosis.International journal of surgery (London, England) · 2026Article
- Article
- Resilience and Intrinsic Capacity in Older Adults: A Review of Recent Literature.Journal of clinical medicine · 2025Review
- Association between intrinsic capacity and sarcopenia in older adults with type 2 diabetes: A cross-sectional study.Aging clinical and experimental research · 2025Article
- Associations between intrinsic capacity, plasma p-tau181 and cognitive function over a 5-year follow-up among community-dwelling older adults: a secondary analysis of the MAPT Study.The Journal of frailty & aging · 2025Observational
- Reference centiles for intrinsic capacity to monitor clinical health outcomes in real-world primary care cohorts.Nature aging · 2025Article
- Exploring the relationship between intrinsic capacity and social participation in healthy ageing: Evidence from Singapore.The journal of nutrition, health & aging · 2025Article
- A functional approach to model intrinsic capacity in ageing trajectories.Scientific reports · 2025Article
- Determinants of intrinsic capacity among older adults in low- and middle-income countries: A scoping review.Belitung nursing journal · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIntrinsic capacity is a composite of five domains that summarizes the physical and mental capacities of an individual. Intrinsic capacity is increasing in relevance for adapting health systems to population ageing. Therefore, our objective was to analyse how intrinsic capacity has been assessed in older adults and if these measurements have been validated, as an initial step towards the construction of a standard intrinsic capacity index.
designNarrative review with electronic searches performed in PubMed and Cochrane databases, including the studies which used the term "intrinsic capacity" in the context of human ageing and health. The full text was then accessed to select studies with at least one operationalised domain of intrinsic capacity. We also looked for information on the validity and reliability of the reported measures of intrinsic capacity.
resultsWe included ten articles reporting a quantitative measurement of intrinsic capacity. There were two intrinsic capacity scores which combined retrospective data on the intrinsic capacity domains sub-scores, with low concordance among tests chosen to measure each domain. Two studies reported on reliability and validity of the IC scores. The main gaps in the construction and validation process were a) analysis undertaken with each domain separately rather than for the construct of intrinsic capacity, b) lack of a clear conceptual and operational definition of the vitality domain, c) summary score that depends upon the distribution of the study sample.
conclusionFurther validation of the intrinsic capacity concept is needed, together with more robust approaches to measure it. A standard index of IC has not been validated for translation into clinical or research purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.