Evidence map›Paper›PMID 33155545›Full record

ArticleeLife2020

Altered hippocampal-prefrontal communication during anxiety-related avoidance in mice deficient for the autism-associated gene

Margaret M Cunniff, Eirene Markenscoff-Papadimitriou, Julia Ostrowski, John Lr Rubenstein, Vikaas Singh Sohal

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 41 citations in OpenAlex.

  1. Article
  2. Article
  3. Autism-associatedProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Prefrontal Cortical Control of Anxiety: Recent Advances.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023
    Review
  16. Prefrontal Interneurons: Populations, Pathways, and Plasticity Supporting Typical and Disordered Cognition in Rodent Models.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Review
  17. Article
  18. Article
  19. Review
  20. Neuronal oscillations: early biomarkers of psychiatric disease?Frontiers in behavioral neuroscience · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Margaret M CunniffDepartment of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
Eirene Markenscoff-PapadimitriouDepartment of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
Julia OstrowskiDepartment of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.
John Lr RubensteinDepartment of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-4414-7667
Vikaas Singh SohalDepartment of Psychiatry, Weill Institute for Neurosciences, and Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, United States.ORCID 0000-0002-2238-4186
University of California, San Francisco · US

Funding

How is anxiety-related information relayed across hippocampal-prefrontal circuitsR01MH117961 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A, SOHAL, VIKAAS SINGH · 2019 to 2022
$2.3M
How is anxiety-related information relayed across hippocampal-prefrontal circuitsR56MH117961 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A, SOHAL, VIKAAS SINGH · 2018 to 2018
$689k
NIMH NIH HHS R01 MH117961NIMH NIH HHS R56 MH117961Simons Foundation 399853Simons Foundation 514438
6 · The paper itself

Abstract

Many genes have been linked to autism. However, it remains unclear what long-term changes in neural circuitry result from disruptions in these genes, and how these circuit changes might contribute to abnormal behaviors. To address these questions, we studied behavior and physiology in mice heterozygous for

Indexed as

AnimalsAnxietyAutistic DisorderAvoidance LearningCommunicationFemaleHeterozygoteHippocampusInterneuronsMaleMiceNeurosciencesPrefrontal CortexPyramidal CellsTheta RhythmTransposasesTransposasesanxietyautismhippocampusmouseneuroscienceprefrontal cortextheta rhythm

Identifiers

PMID33155545
PMCPMC7682992
OpenAlexW3095525855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.