Evidence map›Paper›PMID 33155181›Full record

ArticleJournal of endocrinological investigation2021

Thyroid nodules in xeroderma pigmentosum patients: a feature of premature aging.

S D Kouatcheu, J Marko, D Tamura, S G Khan, C R Lee, J J DiGiovanna, K H Kraemer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of endocrinological investigation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Xeroderma Pigmentosum: A Model for Human Premature Aging.The Journal of investigative dermatology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

S D KouatcheuLaboratory of Cancer Biology and Genetics, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-6339-5893
J MarkoClinical Center, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4281-0306
D TamuraLaboratory of Cancer Biology and Genetics, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.
S G KhanLaboratory of Cancer Biology and Genetics, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9957-4132
C R LeeLaboratory of Pathology, CCR, NCI, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5306-7781
J J DiGiovannaLaboratory of Cancer Biology and Genetics, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2750-2313
K H KraemerLaboratory of Cancer Biology and Genetics, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health (NIH), Bethesda, MD, USA. kraemerk@mail.nih.gov.ORCID http://orcid.org/0000-0002-2689-3316
National Institutes of Health · USCenter for Cancer Research · USNational Institutes of Health Clinical Center · US

Funding

DNA Repair in Human Cancer-Prone Genetic DiseasesZIABC004517 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KRAEMER, KENNETH H · 2009 to 2024
$26.5M
DNA REPAIR IN HUMAN CANCER-PRONE GENETIC DISEASESZ01BC004517 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KRAEMER, KENNETH H · 1996 to 2008
$2.7M
Center for Cancer Research, National Cancer Institute (US) Intramural ResearchIntramural NIH HHS Z01 BC004517Intramural NIH HHS ZIA BC004517
6 · The paper itself

Abstract

purposeXeroderma pigmentosum (XP) is an autosomal recessive disease with defective DNA repair, a markedly increased risk of skin cancer, and premature aging. Reports from North Africa have described thyroid nodules in XP patients, but thyroid nodule prevalence has never been determined in XP patients enrolled in our natural history study at the National Institutes of Health (NIH).

methodsWe performed thyroid ultrasound examinations on all 29 XP patients examined from 2011 to 2019 and assessed nodule malignancy using the Thyroid Imaging Reporting and Data System. Thyroid nodule prevalence was also obtained from comparison cohorts. DNA sequencing was performed on thyroid tissue from XP patients who had surgery for thyroid cancer.

resultsThyroid nodules were identified in 18/29 XP patients (62%). The median age of patients with thyroid nodules in our XP cohort (20 years) was younger than that of three comparison groups: 36 years (California study-208 subjects), 48 years (Korean study-24,757 subjects), and 52 years (NIH-682 research subjects). Multiple (2-4) thyroid nodules were found in 12/18 (67%) of the patients with nodules. Autopsy examination revealed follicular adenomas in 4/8 (50%) additional XP patients. DNA sequencing revealed rare mutations in two other XP patients with papillary thyroid cancer.

conclusionsXP patients have an increased incidence of thyroid nodules at an early age in comparison to the general population. These finding confirm another premature aging feature of XP.

Indexed as

AdolescentAdultAging, PrematureChildFemaleFollow-Up StudiesHumansMaleMarylandMiddle AgedPrognosisThyroid NoduleXeroderma PigmentosumYoung AdultDNA repairDNA sequencingThyroid cancerThyroid nodulesThyroid ultrasoundXeroderma pigmentosum

Identifiers

PMID33155181
PMCPMC8096868
OpenAlexW3094719516

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.