ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2021
How does genetic testing influence anxiety, depression, and quality of life? A hereditary breast and ovarian cancer syndrome suspects trial.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Cancer-Related Psychological Distress over the Past Decade: A Bibliometric Analysis of Research Trends, Hotspots, and Emerging Areas.Healthcare (Basel, Switzerland) · 2026Review
- Psychological distress and cancer worry in unaffected relatives undergoing cascade testing with multigene panel testing.Journal of human genetics · 2026Article
- Investigation on the Anxiety and Depression Status of Thalassemia Carriers After Genetic Counseling.Neuropsychiatric disease and treatment · 2025Article
- Behavioural analysis of referral and uptake of care pathways for rare tumour risk syndromes: A cross-cultural mixed-methods study protocol within the PREVENTABLE project.Open research Europe · 2025Article
- Article
- Quality of Life and Anxiety Status of Patients with Ovarian Tumor Undergoing Enhanced Recovery after Surgery.Actas espanolas de psiquiatria · 2024Article
- Factors associated with psychological distress during genetic counseling in high-risk women with breast cancer in Turkey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEmotional distress associated with genetic testing for hereditary breast and ovarian cancer syndrome (HBOC) is reported to interfere with adherence to treatment and prophylactic measures and compromise quality of life.
objectivesTo determine levels of anxiety, depression, and quality of life in patients tested for pathogenic BRCA1/2 mutations and identify risk factors for the development of adverse psycho-emotional effects.
methodsCross-sectional observational trial involving 178 breast or ovarian cancer patients from a referral cancer hospital in Northeastern Brazil. Information was collected with the Hospital Anxiety and Depression Scale (HADS) and the World Health Organization (WHO) Quality of Life (QoL) questionnaire (WHOQOL-BREF).
resultsPatients suspected of HBOC had higher levels of anxiety than depression. The presence of (probably) pathogenic BRCA1/2 mutations did not affect levels of anxiety and depression. High schooling, history of psychiatric disease, and use of psychotropic drugs were directly associated with high anxiety. High schooling was too inversely associated with QoL as such a breast tumor. Anxiety and depression were directly correlated and both reduced significantly QoL.
conclusionOur results highlight the importance of psychological support and screening of risk factors for anxiety and depression and low QoL in HBOC patients at the time of testing.
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