Evidence map›Paper›PMID 33154965›Full record

ArticleFrontiers in bioengineering and biotechnology2020

Microfluidic Encapsulation of Single Cells by Alginate Microgels Using a Trigger-Gellified Strategy.

Fei Shao, Lei Yu, Yang Zhang, Chuanfeng An, Haoyue Zhang, Yujie Zhang, Yi Xiong, Huanan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Droplets microfluidics platform-A tool for single cell research.Frontiers in bioengineering and biotechnology · 2023
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Microfluidic Chip Device forLangmuir : the ACS journal of surfaces and colloids · 2021
    Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Fei ShaoKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Lei YuKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Yang ZhangLaboratory of Regenerative Biomaterials, Department of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
Chuanfeng AnKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Haoyue ZhangKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Yujie ZhangKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Yi XiongLaboratory of Regenerative Biomaterials, Department of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.
Huanan WangKey State Laboratory of Fine Chemicals, School of Bioengineering, Dalian University of Technology, Dalian, China.
Dalian University · CNDalian University of Technology · CNShenzhen University Health Science Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microfluidics-based alginate microgels have shown great potential to encapsulate cells in a high-throughput and controllable manner. However, cell viability and biological functions are substantially compromised due to the harsh conditions for gelation, which remains a major challenge for cell encapsulation. Herein, we presented an efficient and biocompatible method by on-chip triggered gelation to generate microfluidic alginate microgels for single-cell encapsulation. Two calcium complexes of calcium-ethylenediaminetetraacetic acid (Ca-EDTA) and calcium-nitrilotriacetic (Ca-NTA) as crosslinkers for triggered gelation of alginate were compared and investigated for feasible application. By triggered release of Ca

Indexed as

alginate microgelsbiocomatabilitycalcium complexescell encapsulationmicrofluidicson-chip gelation

Identifiers

PMID33154965
PMCPMC7591722
OpenAlexW3092890201

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.