ArticleJournal of the Saudi Heart Association2020
Systemic immune-inflammation index predicts mortality in infective endocarditis.
Article in Journal of the Saudi Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Diagnostic and prognostic value of systemic immune-inflammation index for heart failure: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Systemic Inflammatory and Hematologic Biomarkers in Pediatric Dental Caries: Clear Group Differences with Limited Independent Association with DMFT.Journal of clinical medicine · 2026Article
- Prognostic Value of HALP Score for In-Hospital Mortality in Patients with Infective Endocarditis.Journal of clinical medicine · 2026Article
- Linear association between the systemic immune-inflammation index and all-cause mortality in patients with interstitial lung disease: a retrospective cohort study.Frontiers in medicine · 2026Article
- Article
- Comparison of systemic inflammatory markers in total knee arthroplasty under spinal vs general anesthesia: a retrospective study.BMC anesthesiology · 2025Article
- Evaluation of the systemic immune-inflammation index in relation to histological stages of celiac disease.European journal of medical research · 2025Article
- Prognostic impact of systemic immune inflammatory index in patients with reduced ejection fraction heart failure.BMC cardiovascular disorders · 2025Article
- Evaluation of Systemic Inflammation in Children with Untreated Dental Caries.Oral health & preventive dentistry · 2025Article
- Predictive strength of inflammatory scores for in-hospital mortality in infective endocarditis.Herz · 2025Article
- New Systemic Inflammatory Indices as Predictors of Fulminant Myocarditis in Children.Diagnostics (Basel, Switzerland) · 2025Article
- Observational
- Early and Long-Term Outcomes of Patients Undergoing Surgery for Native and Prosthetic Valve Endocarditis: The Role of Preoperative Neutrophil-to-Lymphocyte Ratio, Neutrophil-to-Platelet Ratio, and Monocyte-to Lymphocyte Ratio.Journal of clinical medicine · 2025Article
- The Influence of Characteristics and Indexes (NLR, PNI, and SII) Evaluated at Admission on the Mortality Prediction of Infectious Endocarditis Patients.International journal of general medicine · 2025Article
- Association Between the Systemic Immune-Inflammation Index and 24-week Outcomes in Patients with HIV-Associated Cryptococcal Meningitis: Secondary Analysis of a Prospective Multicenter Cohort Study.Journal of inflammation research · 2025Article
- Incidence and risk factors of pain following breast cancer surgery: a retrospective national inpatient sample database study.BMC women's health · 2024Article
- Evaluating the prognostic value of systemic immune-inflammatory index in patients with acute decompensated heart failure.ESC heart failure · 2024Article
- The relationship between severity of periapical periodontitis and next-generation systemic inflammatory biomarkers in children with early childhood caries.BMC oral health · 2024Article
- The prognostic value of dynamic changes in SII for the patients with STEMI undergoing PPCI.BMC cardiovascular disorders · 2024Article
- Prognostic role of systemic immune-inflammation index versus other cardiac markers in acute myocarditis in young adults.Biomarkers in medicine · 2024Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe aim of our study was to evaluate the usefulness of systemic immune-inflammation index (SII) at admission in predicting in-hospital mortality in patients with infective endocarditis.
methods133 definite IE patients (≥18 years) according to modified Duke criteria, treated in our tertiary care hospital between December 2009 and May 2019, were retrospectively analysed. Symptoms, comorbidities, predisposing valvular diseases, prosthetic valve, device, history of injectable drug use, blood culture results, echocardiography findings, and complications were collected. We calculated the SII as follows: SII = platelet count × neutrophil count/lymphocyte count at admission.
resultsThe median age of the patients was 56 (40-66) years. Prosthetic valve disease was the most frequent predisposing valve lesion. Staphylococcus species were the most common microorganisms. The most frequent complication was in-hospital mortality (22%) followed by renal failure. Older population, syncope, increased inflammatory markers, high systolic pulmonary artery pressure (PAPs), heart failure, renal failure, and septic shock were associated with high mortality. However age, syncope, hypocalcemia, not going to surgery, and SII were independent predictors of in-hospital mortality. According to receiver operating characteristic curve analysis, the optimal SII cut-off value for predicting mortality was 2314 (area under the curve 0.641;
conclusionWe demonstrated that high SII levels are independently associated with in-hospital mortality. The SII may be a promising prognostic predictor for patients with infective endocarditis.
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