ArticleFrontiers in immunology2020
Single-Cell Transcriptome Profiling of Immune Cell Repertoire of the Atlantic Cod Which Naturally Lacks the Major Histocompatibility Class II System.
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Loss of Major Histocompatibility Complex I and II Function in the Genome of Glacier Lanternfish Provides Insight Into Evolution of Vertebrate Immune Systems.Genome biology and evolution · 2026Article
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- IgM-mediated protection drives early B-cell activation and mucosal containment ofFrontiers in immunology · 2026Article
- Single-cell atlas of grass carp (Zoological research · 2025Article
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- Gene Expression and Phenotypic Assessment of Egg Quality across Developmental Stages of Atlantic Cod throughout the Spawning Season.International journal of molecular sciences · 2024Article
- Slc43a2Science China. Life sciences · 2024Article
- Single-cell atlas of rainbow trout peripheral blood leukocytes and profiling of their early response to infectious pancreatic necrosis virus.Frontiers in immunology · 2024Article
- Single-cell transcriptome analysis of medaka lymphocytes reveals absence of fully mature T cells in the thymus and the T-lineage commitment in the kidney.Frontiers in immunology · 2024Article
- Single cell genomics as a transformative approach for aquaculture research and innovation.Reviews in aquaculture · 2023Review
- Advances in the Xenopus immunome: Diversification, expansion, and contraction.Developmental and comparative immunology · 2023Review
- Single-Cell RNA Sequencing Reveals Microevolution of the Stickleback Immune System.Genome biology and evolution · 2023Article
- A Call For More Ecologically And Evolutionarily Relevant Studies of Immune Costs.Evolutionary ecology · 2023Article
- Evolution and Potential Subfunctionalization of DuplicatedJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- Lymphocyte subsets in Atlantic cod (Gadus morhua) interrogated by single-cell sequencing.Communications biology · 2022Article
- Multi-tissue scRNA-seq reveals immune cell landscape of turbot (Fundamental research · 2022Article
- Characterization of Pipefish Immune Cell Populations Through Single-Cell Transcriptomics.Frontiers in immunology · 2022Article
- Single cell transcriptomics of Atlantic salmon (Frontiers in immunology · 2022Article
- NKB cells: A double-edged sword against inflammatory diseases.Frontiers in immunology · 2022Review
- RNA-Seq of Single Fish Cells - Seeking Out the Leukocytes Mediating Immunity in Teleost Fishes.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Atlantic cod's unusual immune system, entirely lacking the Major Histocompatibility class II pathway, has prompted intriguing questions about what mechanisms are used to combat bacterial infections and how immunological memory is generated. By single-cell RNA sequencing we here report an in-depth characterisation of cell types found in immune tissues, the spleen and peripheral blood leukocytes of Atlantic cod. Unbiased transcriptional clustering revealed eleven distinct immune cell signatures. Resolution at the single cell level enabled characterisation of the major cell subsets including the cytotoxic T cells, B cells, erythrocytes, thrombocytes, neutrophils, and macrophages. Additionally, to our knowledge we are the first to uncover cell subsets in Atlantic cod which may represent dendritic cells, natural killer-like cells, and a population of cytotoxic cells expressing
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