ArticleClinical ophthalmology (Auckland, N.Z.)2020
Microbial Keratitis in Corneal Transplants: A 12-Year Analysis.
Article in Clinical ophthalmology (Auckland, N.Z.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Incidence, causative pathogens, risk factors, geographical variations, and outcomes of post-keratoplasty infectious keratitis over the last 15 years: a systematic review and meta-analysis.International ophthalmology · 2025Pooled it
- The public health impact of making chloramphenicol an over-the-counter antibiotic: a systematic literature review.International ophthalmology · 2025Pooled it
- Evaluation of Tissue-C and CorneaMax organ culture media for microbial contamination detection in corneal grafts using the BD BACTEC FX system.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Keratitis after keratoplasty: risk modifiers, microbial resistance and outcomes in the COVID-19 era.International ophthalmology · 2025Article
- Comparative Evaluation of Temperature, Bottle Type, and Amphotericin B on Fungal Detection in Corneal Preservation Media Using the BACT/ALERT SystemMicroorganisms · 2025Article
- Outcomes of Post-Keratoplasty Microbial Keratitis: A 16-Year Analysis.Journal of clinical medicine · 2025Article
- Severe Microbial Keratitis in Virgin and Transplanted Cornea-Probability of Visual Acuity Improvement.Journal of clinical medicine · 2024Article
- Infectious crystalline keratopathy-clinical-microbiological profile and outcome of management.International ophthalmology · 2024Article
- Microbiological screening of corneas stored in organ culture medium at Lions Eye Bank of Western Australia from 2011 to 2022.International ophthalmology · 2024Article
- Post-Keratoplasty Microbial Keratitis in the Era of Lamellar Transplants-A Comprehensive Review.Journal of clinical medicine · 2024Review
- Infectious keratitis in Western New York: a 10-year review of patient demographics, clinical management, and treatment failure.Frontiers in ophthalmology · 2024Article
- An Overview of Corneal Transplantation in the Past Decade.Clinics and practice · 2023Review
- A 7-year review of clinical characteristics, predisposing factors and outcomes of post-keratoplasty infectious keratitis: the Nottingham infectious keratitis study.Frontiers in cellular and infection microbiology · 2023Article
- Impact of the COVID-19 Pandemic on the Incidence and Characteristics of Culture-Positive Microbial Keratitis at a Tertiary Eye Hospital in the UK.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Current Perspectives on Corneal Transplantation.Clinical ophthalmology (Auckland, N.Z.) · 2022Review
- Post-keratoplasty Infectious Keratitis: Epidemiology, Risk Factors, Management, and Outcomes.Frontiers in medicine · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the frequencies, trends, and in vitro drug susceptibilities of the causative pathogens in corneal transplant microbial infections in Manchester Royal Eye Hospital.
methodsCorneal scrape results recorded by the microbiology service between 2004 and 2015 were extracted from an established database. This microbiological data was matched with a separate database of all corneal transplant procedures performed in our centre over this time period. Patient records were examined to collect specific patient data and to confirm the diagnosis of microbial keratitis.
resultsA total of 1508 grafts had been performed at our centre in this period. 72 episodes of graft microbial keratitis were identified from 66 eyes that had undergone keratoplasty procedures. Mean age was 56, and 51% of subjects were male. Ninety-three percent of microbial keratitis episodes occurred in penetrating keratoplasty procedures and 6% in deep anterior lamellar keratoplasty procedures. No endothelial grafts presented with infections throughout this time period. Of the 79 organisms identified, 73% were gram positive, 23% gram negative and 4% fungi. With regard to gram-positive organisms, vancomycin and gentamicin showed 100% and 91% susceptibility, respectively. Ofloxacin had a resistance rate of 13.7%. In terms of gram-negative organisms, gentamicin and chloramphenicol showed 100% sensitivity, with cefuroxime showing 69%. Resistance rates were less than 15% in all tested gram-negative antimicrobials.
conclusionThis paper describes the largest collection of corneal transplant infections identified within the UK. This finding may aid clinicians in predicting possible causative organisms for microbial keratitis and aid antibiotic choice.
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