ArticleNature immunology2021
Distinct antibody responses to SARS-CoV-2 in children and adults across the COVID-19 clinical spectrum.
Open access · bronzeAbstract read
In one paragraph
Article in Nature immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 329 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
329citing papers in PubMed, 2 pooled it
11.2field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
329 citing papers in PubMed, 2 syntheses or guidelines pooled it, 547 citations in OpenAlex.
- Long-Term Complications of Multisystem Inflammatory Syndrome in Children and Adults Post-COVID-19: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- The protective effect of COVID-19 vaccines on developing multisystem inflammatory syndrome in children (MIS-C): a systematic literature review and meta-analysis.Pediatric rheumatology online journal · 2023Pooled it
- Immunogenicity, safety and consistency of seven lots of an inactivated COVID-19 vaccine in healthy children and adolescents: a randomized, double-blind, controlled, phase IV clinical trial.Frontiers in immunology · 2023Trial
- Article
- Immune correlates of risk for SARS-CoV-2 infection in children: a prospective, community-based cohort study.Nature communications · 2026Article
- Antibody repertoire associated with clinically diverse presentations of pediatric SARS-CoV-2 infection.Scientific reports · 2026Article
- Pediatric SARS-CoV-2 outcomes study (PECOS): 12-month longitudinal analysis of post-COVID symptoms in infected versus uninfected participants.Pediatric research · 2026Article
- Mechanisms underlying immunodynamics of layered defenses elicited by mRNA vaccination in children.BMC medicine · 2026Article
- Comparative analysis of adaptive immunity to SARS-CoV-2 in infected children and adults.Pediatric research · 2026Article
- Salivary IgG Antibody Response to SARS-CoV-2 as a Non-Invasive Assessment of Immune Response-Differences Between Vaccinated Children and Adults.Biomedicines · 2026Article
- A perfect storm: the immunological and pathophysiological landscape of pediatric post-COVID-19 condition.Frontiers in immunology · 2026Review
- Development of seropositivity to SARS-CoV-2 over the course of the COVID-19 pandemic in adolescents in a longitudinal cohort study in Cebu, Philippines.PLOS global public health · 2026Article
- Article
- "Characteristics of children with multisystem inflammatory syndrome in children during different COVID-19 waves "Single centre Study".BMC pediatrics · 2025Observational
- Characterising protective immune responses to SARS-CoV-2 in urban and rural Malawi between February 2021 and April 2022.Scientific reports · 2025Article
- Article
- Immunological Mechanisms Underlying Allergy Predisposition After SARS-CoV-2 Infection in Children.Cells · 2025Review
- The interplay of influenza and COVID-19 in Germany, January 2020 - December 2022: a study of competitive disease dynamics with quarantine measures and partial cross-immunity.BMC public health · 2025Article
- Advancements and Future Perspectives of Microfluidic Technology in Pediatric Healthcare.Smart medicine · 2025Review
- Article
269 more citing papers are in PubMed but not listed here.
Corrections and comments
- Update of
Authors and funding
31 authors at 4 institutions in 3 countries.
Stuart P Weisberg *Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8698-5976
Thomas J Connors *Department of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0199-7733
Yun ZhuDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Matthew R BaldwinDepartment of Medicine, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4670-3433
Wen-Hsuan LinDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5414-7900
Sandeep WontakalDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0889-032X
Peter A SzaboColumbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-1603-761X
Steven B WellsDepartment of Systems Biology, Columbia University Irving Medical Center, New York, NY, USA.
Pranay DograColumbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Joshua GrayColumbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Emma IdzikowskiDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Debora StelitanoDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Francesca T BovierDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Julia Davis-PoradaMedical Scientist Training Program, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0001-9313-4590
Rei MatsumotoColumbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.
Maya Meimei Li PoonColumbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7927-5853
Michael ChaitDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Cyrille MathieuCIRI, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale, U1111, Claude Bernard University Lyon 1, Centre National de la Recherche Scientifique, UMR5308, École Normale Supérieure de Lyon, Lyon, France.ORCID http://orcid.org/0000-0002-6682-2029
Branka HorvatCIRI, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale, U1111, Claude Bernard University Lyon 1, Centre National de la Recherche Scientifique, UMR5308, École Normale Supérieure de Lyon, Lyon, France.ORCID http://orcid.org/0000-0003-0578-7765
Didier DecimoCIRI, Centre International de Recherche en Infectiologie, Institut National de la Santé et de la Recherche Médicale, U1111, Claude Bernard University Lyon 1, Centre National de la Recherche Scientifique, UMR5308, École Normale Supérieure de Lyon, Lyon, France.
Krystalyn E HudsonDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Flavia Dei ZottiDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Zachary C BitanDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Francesca La CarpiaDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-1120-9307
Stephen A FerraraSchool of Nursing, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-2287-8255
Emily MaceDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-0226-7393
Joshua MilnerDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Anne MosconaDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA.
Eldad HodDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2367-9509
Matteo PorottoDepartment of Pediatrics, Columbia University Irving Medical Center, New York, NY, USA. mp3509@cumc.columbia.edu.ORCID http://orcid.org/0000-0003-3866-9220
Donna L FarberColumbia Center for Translational Immunology, Columbia University Irving Medical Center, New York, NY, USA. df2396@cumc.columbia.edu.ORCID http://orcid.org/0000-0001-8236-9183
Columbia University Irving Medical Center · USUniversité Claude Bernard Lyon 1 · FRUniversity of Campania "Luigi Vanvitelli" · ITColumbia University · US
Funding
Viral Assays CoreU19AI128949 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Donna L. Farber, Peter Alan Sims · 2017 to 2026
$26.4MDevelopment of lung T cell responses in infant respiratory immunityU01AI100119 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FARBER, DONNA L. · 2017 to 2021
$3.9MEngineering protease-resistant alpha-beta peptides for broad-spectrum antiviralsR01AI114736 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI MOSCONA, ANNE · 2015 to 2019
$3.7MDevelopment of novel endosome-targeted Ebola virus entry inhibitors as antiviral agentsR01AI121349 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI POROTTO, MATTEO · 2016 to 2020
$3.2MMechanisms of measles virus CNS adaptationR01NS091263 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI POROTTO, MATTEO · 2015 to 2019
$1.9MDevelopment of therapeutic fusion inhibitor peptides for Measles encephalitisR01NS105699 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI POROTTO, MATTEO · 2018 to 2022
$1.8MCAPRI: Columbia Cancer Training Program for Resident-InvestigatorsR38CA231577 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CREW, KATHERINE D, SCHWARTZ, GARY K · 2018 to 2021
$1.4MDevelopment of Localized T Cell Immunity in Pediatric Respiratory Tract InfectionK23AI141686 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CONNORS, THOMAS · 2019 to 2023
$973kTissue Resident Immune Cells in Human Pancreas.K08DK122130 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WEISBERG, STUART P · 2019 to 2023
$827kCancer Research Institute (CRI) fellowshipNCI NIH HHS R38 CA231577NIAID NIH HHS K23 AI141686NIAID NIH HHS U01 AI100119NIAID NIH HHS U19 AI128949NIDDK NIH HHS K08 DK122130U.S. Department of Health & Human Services | National Institutes of Health (NIH) AI146980U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI100119U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI114736U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI121349U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI128949U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI141686U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) K08DK122130U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS091263U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS105699
Abstract
Clinical manifestations of COVID-19 caused by the new coronavirus SARS-CoV-2 are associated with age
Indexed as
AdolescentAdultAgedAntibodies, ViralAntibody FormationChildChild, PreschoolCOVID-19FemaleHumansImmunoglobulin AImmunoglobulin GImmunoglobulin MMaleMiddle AgedNucleocapsid ProteinsAntibodies, ViralImmunoglobulin AImmunoglobulin GImmunoglobulin MNucleocapsid ProteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.