Evidence map›Paper›PMID 33154433›Full record

ArticleScientific reports2020

Efficacy based ginger fingerprinting reveals potential antiproliferative analytes for triple negative breast cancer.

Lihan Zhao, Manali Rupji, Ishita Choudhary, Remus Osan, Shobhna Kapoor, Hong-Jie Zhang, Chunhua Yang, Ritu Aneja

Abstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
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  5. Article
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  7. Article
  8. Effects of dazomet combined withFrontiers in microbiology · 2022
    Article
  9. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lihan ZhaoDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Manali RupjiBiostatistics and Bioinformatics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, 30322, USA.
Ishita ChoudharyDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA.
Remus OsanDepartment of Math and Stats, Georgia State University, Atlanta, GA, 30303, USA.
Shobhna KapoorDepartment of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai, Maharashtra, 400076, India.
Hong-Jie ZhangSchool of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong.
Chunhua YangInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA, 30303, USA. cyang16@gsu.edu.
Ritu AnejaDepartment of Biology, Georgia State University, Atlanta, GA, 30303, USA. raneja@gsu.edu.

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
Evaluation of HSET as a Novel Theranostic Target for Breast Cancer TherapyR01CA169127 · NCI · GEORGIA STATE UNIVERSITY · PI ANEJA, RITU · 2012 to 2016
$1.7M
NCI NIH HHS P30 CA138292NCI NIH HHS R01 CA169127NIH HHS R01 CA169127
6 · The paper itself

Abstract

Ginger (Zingiber officinale) is one of the most widely consumed dietary supplements worldwide. Its anticancer potential has been demonstrated in various studies. However, ginger roots obtained from different geographical locations showed extensive variability in their activities, mainly due to differences in the levels of bioactive compounds. Here we evaluated the effect of these differences on the anticancer activity of ginger by performing efficacy-based fingerprinting. We characterized the fingerprint profiles of 22 ginger samples using liquid chromatography-mass spectroscopy, followed by a principal component analysis (PCA) and pearson correlation analysis. We also evaluated the anti-proliferative effects (IC

Indexed as

Cell Line, TumorCell ProliferationChromatography, LiquidDNA FingerprintingHumansMass SpectrometryPlant ExtractsTriple Negative Breast NeoplasmsZingiber officinalePlant Extracts

Identifiers

PMID33154433
PMCPMC7644756

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.