ArticleScientific reports2020
The antibacterial and angiogenic effect of magnesium oxide in a hydroxyapatite bone substitute.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 71 citations in OpenAlex.
- A pH-Triggered antibacterial and lubricating dual-function hydrogel coating for infection-resistant urinary catheters.Frontiers in bioengineering and biotechnology · 2026Article
- Coupled osteogenesis and angiogenesis on 3D-printed highly porous PCL/magnesium/laponite nanocomposite scaffold.Scientific reports · 2025Article
- Comparative Effects of ZnO, MgO, and CaO Nanoparticles in 3D-Printed Chitosan-Agarose Scaffolds on Antibacterial and Osteogenic Outcomes.Macromolecular bioscience · 2025Article
- Characterization of Eco-Friendly Fabricated and Induction-Sintered Hydroxyapatite-Based Hybrid Composites.Materials (Basel, Switzerland) · 2025Article
- Towards Safe and Effective Biomedical Nanocoatings: Plasma-Sputtered Magnesium-Based Nanoparticles with Cytoprotective, Antimicrobial and Antialgal Properties.Molecules (Basel, Switzerland) · 2025Article
- Novel Nanomaterials for Developing Bone Scaffolds and Tissue Regeneration.Nanomaterials (Basel, Switzerland) · 2025Review
- Hyaluronan-Containing Injectable Magnesium-Calcium Phosphate Cements Demonstrated Improved Performance, Cytocompatibility, and Ability to Support Osteogenic Differentiation In Vitro.International journal of molecular sciences · 2025Article
- Versatile application of magnesium-related bone implants in the treatment of bone defects.Materials today. Bio · 2025Review
- Magnesium-enhanced porcine particles using hydrothermal technique improve the osteogenic differentiation of cells.RSC advances · 2024Article
- Composite Mineralized Collagen/Polycaprolactone Scaffold-Loaded Microsphere System with Dual Osteogenesis and Antibacterial Functions.Polymers · 2024Article
- Microstructural, Fluid Dynamic, and Mechanical Characterization of Zinc Oxide and Magnesium Chloride-Modified Hydrogel Scaffolds.ACS biomaterials science & engineering · 2024Article
- Preparation of a novel antibacterial magnesium carbonate coating on a titanium surface and itsRSC advances · 2024Article
- Pro-angiogenic and antibacterial copper containing nanoparticles in PLGA/amorphous calcium phosphate bone nanocomposites.Heliyon · 2024Article
- Effect of using nano-particles of magnesium oxide and titanium dioxide to enhance physical and mechanical properties of hip joint bone cement.Scientific reports · 2024Article
- Influence of the Addition of Zinc, Strontium, or Magnesium Oxides to the Bioglass 45S5 Network on Electrical Behavior.Materials (Basel, Switzerland) · 2024Article
- Current application and future perspectives of antimicrobial degradable bone substitutes for chronic osteomyelitis.Frontiers in bioengineering and biotechnology · 2024Review
- Advances in magnesium-containing bioceramics for bone repair.Biomaterials translational · 2024Review
- Electrophoretic deposition of magnesium oxide coating on micro-arc oxidized titanium for antibacterial activity and biocompatibility.Journal of orthopaedic surgery and research · 2023Article
- Bioactive Glasses Containing Strontium or Magnesium Ions to Enhance the Biological Response in Bone Regeneration.Nanomaterials (Basel, Switzerland) · 2023Article
- Novel Metal Nanomaterials to Promote Angiogenesis in Tissue Regeneration.Engineered regeneration · 2023Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone graft infections are serious complications in orthopaedics and the growing resistance to antibiotics is increasing the need for antibacterial strategies. The use of magnesium oxide (MgO) is an interesting alternative since it possesses broad-spectrum antibacterial activity. Additionally, magnesium ions also play a role in bone regeneration, which makes MgO more appealing than other metal oxides. Therefore, a bone substitute composed of hydroxyapatite and MgO (HAp/MgO) spherical granules was developed using different sintering heat-treatment cycles to optimize its features. Depending on the sintering temperature, HAp/MgO spherical granules exhibited distinct surface topographies, mechanical strength and degradation profiles, that influenced the in vitro antibacterial activity and cytocompatibility. A proper balance between antibacterial activity and cytocompatibility was achieved with HAp/MgO spherical granules sintered at 1100 ºC. The presence of MgO in these granules was able to significantly reduce bacterial proliferation and simultaneously provide a suitable environment for osteoblasts growth. The angiogenic and inflammation potentials were also assessed using the in vivo chicken embryo chorioallantoic membrane (CAM) model and the spherical granules containing MgO stimulated angiogenesis without increasing inflammation. The outcomes of this study evidence a dual effect of MgO for bone regenerative applications making this material a promising antibacterial bone substitute.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.