ArticleScientific reports2020
Loss of sympathetic innervation to islets of Langerhans in canine diabetes and pancreatitis is not associated with insulitis.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Increase in the prevalence of canine diabetes mellitus in Japan from 2015 to 2023: insights from insurance and clinical data.The Journal of veterinary medical science · 2026Article
- High-resolution imaging atlas reveals the context-dependent role of pancreatic sympathetic innervation in diabetic mice.Acta biochimica et biophysica Sinica · 2025Article
- Day-to-day variability of porcine lente, insulin glargine 300 U/mL and insulin degludec in diabetic dogs.Journal of veterinary internal medicine · 2021Article
- Serum trypsin-like immunoreactivity in dogs with diabetes mellitus.Journal of veterinary internal medicine · 2021Article
- Fenofibrate promotes PPARα-targeted recovery of the intestinal epithelial barrier at the host-microbe interface in dogs with diabetes mellitus.Scientific reports · 2021Article
- Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.Scientific reports · 2021Article
- Freestyle Libre-Derived Metrics in Assessing Glycemic Control in Diabetic Dogs.Journal of veterinary internal medicineArticle
- Histopathological evaluation of the adrenal glands in a cat with primary hypoadrenocorticism and multiple endocrine disease.JFMS open reportsArticle
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Canine diabetes mellitus (DM) affects 0.6% of the canine population and yet, its etiology is poorly understood. Most affected dogs are diagnosed as adults and are insulin-dependent. We compared pan-leukocyte and sympathetic innervation markers in pancreatic islets of adult dogs with spontaneous DM (sDM), spontaneous pancreatitis (sPanc), both (sDMPanc), toxin-induced DM (iDM) and controls. We found evidence of decreased islet sympathetic innervation but no significant infiltration of islets with leukocytes in all disease groups. We show that loss of sympathetic innervation is ongoing in canine DM and does not necessarily precede it. We further found selective loss of islet-associated beta cells in dogs with sDM and sDMPanc, suggesting that collateral damage from inflammation in the exocrine pancreas is not a likely cause of DM in these dogs. The cause of this selective loss of beta cells needs to be further elucidated but overall, our findings are not supportive of an autoimmune process as a cause of sDM in adult dogs. The loss of sympathetic innervation in sPanc in dogs that do not suffer from DM links the disease in the exocrine pancreas to a pathological process in the endocrine pancreas, suggesting pancreatitis might be a potential precursor to DM.
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