Evidence map›Paper›PMID 33154182›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2020

Efficacy of spoken word comprehension therapy in patients with chronic aphasia: a cross-over randomised controlled trial with structural imaging.

Victoria Fleming, Sonia Brownsett, Anna Krason, Maria A Maegli, Henry Coley-Fisher, Yean-Hoon Ong, Davide Nardo, Rupert Leach, David Howard, Holly Robson and 5 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02540889 (Listen-In), which is not on this map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02540889 nacompletednot on this map

Listen-In: the Development and Testing of a Web-based Therapy Application for Patients With Impaired Speech Comprehension Caused by Stroke

TypeinterventionalSponsorUniversity College, LondonRan2016 to 2018Enrolled36ConditionsAphasiaArmsAuditory comprehension therapy.
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Rehabilitation interventions for Wernicke's aphasia and related fluent aphasia: A systematic review of randomized controlled trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Pooled it
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  13. Treatment of post-stroke aphasia: A narrative review for stroke neurologists.International journal of stroke : official journal of the International Stroke Society · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 4 countries.

Victoria Fleming *UCL Queen Square Institute of Neurology, University College London, London, UK victoria.fleming@ucl.ac.uk.ORCID http://orcid.org/0000-0003-2582-4914
Sonia Brownsett *School of Health and Rehabilitation Sciences, The University of Queensland, Saint Lucia, Queensland, Australia.
Anna KrasonDepartment of Psychology and Language Sciences, University College London, London, UK.
Maria A MaegliDepartment of Psychology, Universidad del Valle de Guatemala, Guatemala, Guatemala.
Henry Coley-FisherUCL Queen Square Institute of Neurology, University College London, London, UK.
Yean-Hoon OngUCL Queen Square Institute of Neurology, University College London, London, UK.
Davide NardoMRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, Cambridgeshire, UK.
Rupert LeachUCL Queen Square Institute of Neurology, University College London, London, UK.
David HowardSchool of Education, Communication and Language Sciences, Newcastle University, Newcastle upon Tyne, Tyne and Wear, UK.
Holly RobsonPsychology and Clinical Language Sciences, University of Reading, Reading, Berkshire, UK.
Elizabeth WarburtonDepartment of Medicine, University of Cambridge, Cambridge, Cambridgeshire, UK.
John AshburnerWellcome Centre for Human Neuroimaging, University College London, London, UK.
Cathy J PriceWellcome Centre for Human Neuroimaging, University College London, London, UK.
Jenny T CrinionInstitute of Cognitive Neuroscience, University College London, London, UK.
Alexander P LeffUCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0002-0831-3541
National Hospital for Neurology and Neurosurgery · GBLanguage Science (South Korea) · KRUniversity College London · GBWellcome Centre for Human Neuroimaging · GBMRC Cognition and Brain Sciences Unit · GBQueen Mary University of London · GBThe University of Queensland · AUUniversidad del Valle de Guatemala · GTUniversity of Cambridge · GB

Funding

Department of Health II-LB-0813-20004Medical Research Council G0701888Medical Research Council MC_UU_00005/1Medical Research Council MR/M023672/1Wellcome Trust 205103/Z/16/Z
6 · The paper itself

Abstract

objectiveThe efficacy of spoken language comprehension therapies for persons with aphasia remains equivocal. We investigated the efficacy of a self-led therapy app, 'Listen-In', and examined the relation between brain structure and therapy response.

methodsA cross-over randomised repeated measures trial with five testing time points (12-week intervals), conducted at the university or participants' homes, captured baseline (T

resultsThirty-five participants completed, on average, 85 hours (IQR=70-100) of Listen-In (therapy first, n=18). The first study-specific co-primary outcome (Auditory Comprehension Test (ACT)) showed large and significant improvements for trained spoken words over therapy versus standard care (11%, Cohen's d=1.12). Gains were largely maintained at 12 and 24 weeks. There were no therapy effects on the second standardised co-primary outcome (Comprehensive Aphasia Test: Spoken Words and Sentences). Change on ACT trained words was associated with volume of pretherapy right hemisphere white matter and post-therapy grey matter tissue density changes in bilateral temporal lobes.

conclusionsIndividuals with chronic aphasia can improve their spoken word comprehension many years after stroke. Results contribute to hemispheric debates implicating the right hemisphere in therapy-driven language recovery. Listen-In will soon be available on GooglePlay. TRIAL REGISTRATION NUMBER: NCT02540889.

Identifiers

PMID33154182
PMCPMC7611712
OpenAlexW3097008618

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.