Trial reportBMJ open respiratory research2020
Novel electronic adherence monitoring devices in children with asthma: a mixed-methods study.
Trial report in BMJ open respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07224061 (Promoting Asthma Guidelines and Management Through Technology-Based Intervention and Care Coordination in Clinics and Schools), which is not on this map. Cited by 20 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Promoting Asthma Guidelines and Management Through Technology-Based Intervention and Care Coordination in Clinics and Schools (PRAGMATIC-S)
Who cites it
20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The value of qualitative research in randomized controlled trials involving drugs and medical devices: a systematic mapping review.International journal of technology assessment in health care · 2026Pooled it
- Systematic Review of Electronic Monitoring to Increase Medication Adherence in Children With Asthma.Pediatric pulmonology · 2025Pooled it
- Digital remote maintenance inhaler adherence interventions in COPD: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2024Pooled it
- Digital interventions to improve adherence to maintenance medication in asthma.The Cochrane database of systematic reviews · 2022Pooled it
- Unlocking Better Asthma Control: A Narrative Review of Adherence to Asthma Therapy and Innovative Monitoring Solutions.Journal of clinical medicine · 2024Review
- Medication Adherence in Children with Asthma.Patient preference and adherence · 2024Review
- A Review of Sensor-Based Interventions for Supporting Patient Adherence to Inhalation Therapy.Patient preference and adherence · 2024Review
- Article
- Impact of Post-Visit Outreach on Inhaled Corticosteroid Refill Persistence in Children and Young Adults With Asthma.Respiratory care · 2023Article
- eHealth Technologies for Monitoring Pediatric Asthma at Home: Scoping Review.Journal of medical Internet research · 2023Article
- Clinical Impact of Electronic Monitoring Devices of Inhalers in Adults with Asthma or COPD: A Systematic Review and Meta-Analysis.Pharmaceuticals (Basel, Switzerland) · 2023Review
- A scoping review of mHealth monitoring of pediatric bronchial asthma before and during COVID-19 pandemic.Paediatric respiratory reviews · 2022Article
- Assessing adherence to inhaled therapies in asthma and the emergence of electronic monitoring devices.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Development and Feasibility of a Mobile Asthma App for Children and Their Caregivers: Mixed Methods Study.JMIR formative research · 2022Article
- Frontiers Review: Severe Asthma in Adolescents.Frontiers in pediatrics · 2022Review
- The use of remote video directly observed therapy to improve both inhaler technique and adherence to asthma medications.Frontiers in public health · 2022Review
- Digital Inhalers for Asthma or Chronic Obstructive Pulmonary Disease: A Scientific Perspective.Pulmonary therapy · 2021Review
- Article
- Artificial intelligence in respiratory care: Current scenario and future perspective.Annals of thoracic medicineArticle
- A tool for recognizing asthma nonadherence during disease management: A prospective cohort study.Annals of thoracic medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAdherence monitoring to inhaled corticosteroids is an essential component of asthma management. Electronic monitoring devices (EMD) provide objective data on date, time and number of actuations. However, most give no information on inhalation. Novel EMD (NEMD) platforms have the potential to monitor both activation and inhalation.
aimTo assess the feasibility of NEMDs, in terms of usability, acceptability to patients and healthcare professionals and accuracy.
methodsThis was an open-label, prospective, mixed-methods, pragmatic randomised study. Children with asthma attending specialist tertiary care were randomised to one of four NEMD: Remote Directly Observed Therapy (R-DOT), Hailie Smartinhaler, INhaler Compliance Assessment device (INCA) and the Rafi-tone App. Following monitoring, participants were invited to focus groups or one-to-one interviews. Usability and acceptability were evaluated using themes identified from the focus groups and interviews. Adherence accuracy was determined using adherence data from each NEMD.
resultsThirty-five children were recruited; 18 (51%), (11 males, median age 13.5 (7-16) years) completed monitoring, 14 (78%) provided feedback. Participants identified various features such as ease of use and minimal effort as desirable criteria for an NEMD. The Hailie and INCA fulfilled these criteria and were able to record both actuation and inhalation. Negative themes included a 'Big Brother' effect and costs.
conclusionThere was no 'one size fits all', as participants identified advantages and disadvantages for each NEMD. Devices that can easily calculate adherence to activation and inhalation have the potential to have greatest utility in clinical practice. Each NEMD has different functionality and therefore choice of platform should be determined by the needs of the patient and healthcare professional.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.