Evidence map›Paper›PMID 33153990›Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2020

Health-related quality of life of patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

Ingrid A Cox, Nicolas Borchers Arriagada, Barbara de Graaff, Tamera J Corte, Ian Glaspole, Stella Lartey, E Haydn Walters, Andrew J Palmer

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  11. WHODAS 2.0 to Assess Disability in the Rehabilitation of Individuals With Chronic Respiratory Conditions: Responsiveness and Interpretability.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ingrid A CoxMenzies Institute for Medical Research, University of Tasmania, Tasmania, Australia.ORCID https://orcid.org/0000-0001-5130-4088
Nicolas Borchers ArriagadaMenzies Institute for Medical Research, University of Tasmania, Tasmania, Australia.
Barbara de GraaffMenzies Institute for Medical Research, University of Tasmania, Tasmania, Australia.
Tamera J CorteCentre of Research Excellence for Pulmonary Fibrosis, Royal Prince Alfred Hospital, Camperdown, Australia.
Ian GlaspoleCentre of Research Excellence for Pulmonary Fibrosis, Royal Prince Alfred Hospital, Camperdown, Australia.ORCID https://orcid.org/0000-0002-5118-2890
Stella LarteyMenzies Institute for Medical Research, University of Tasmania, Tasmania, Australia.
E Haydn WaltersMenzies Institute for Medical Research, University of Tasmania, Tasmania, Australia.
Andrew J PalmerMenzies Institute for Medical Research, University of Tasmania, Tasmania, Australia andrew.palmer@utas.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease presenting in persons 50 years and older. Through a comprehensive review of available studies, we aimed to assess health-related quality of life (HRQoL) of people living with IPF and the instruments used in this assessment.Searches were conducted up to May, 2020. Quality appraisal and data extraction were performed using pre-designed forms. Narrative synthesis approach was used to report results of the systematic review and a random effects model was used for the meta-analysis. A leave-one-out sensitivity analysis was performed, and a trim and fill method was used to assess publication bias.The review included 134 studies. The most used instruments to measure HRQoL were St George's Respiratory Questionnaire (SGRQ), Short Form 36 (SF36) and EuroQoL (EQ5D). Standardised mean scores (95% confidence interval) for these instruments were as follows: SGRQ total score: 44.72 (42.21-47.22); SF36 physical component score (PCS): 37.00 (34.74-39.26) SF36 mental component score (MCS): 50.18 (48.41-51.95); King's Brief Interstitial Lung Disease questionnaire total score: 58.38 (55.26-61.51); and EQ5D utility: 0.73 (0.68-0.79). Analysis of standardised means for both SGRQ and SF36 demonstrated worse scores in physical health domains as compared to mental health domains.This systematic review confirms that IPF negatively affected HRQoL, mostly impacting the physical health domains. This study also demonstrated that a diverse number of instruments are used to evaluate HRQoL. In view of this diversity, a standardised approach to measurement of HRQoL for IPF is important to ensure that comparisons made are reliable.

Indexed as

Idiopathic Pulmonary FibrosisLung Diseases, InterstitialHumansQuality of LifeSurveys and Questionnaires

Identifiers

PMID33153990
PMCPMC9488638

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.