Evidence map›Paper›PMID 33153394›Full record

ArticleCirculation research2021

Eosinophils Protect Mice From Angiotensin-II Perfusion-Induced Abdominal Aortic Aneurysm.

Cong-Lin Liu, Xin Liu, Yuanyuan Zhang, Jing Liu, Chongzhe Yang, Songyuan Luo, Tianxiao Liu, Yunzhe Wang, Jes S Lindholt, Axel Diederichsen and 9 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 69 citations in OpenAlex.

  1. Predictive Value of PreoperativeInternational journal of molecular sciences · 2026
    Article
  2. Review
  3. Review
  4. Emerging Mechanisms of Abdominal Aortic Aneurysm.Current atherosclerosis reports · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. IRF8 Drives Conventional Type 1 Dendritic Cell Differentiation and CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  15. Article
  16. Article
  17. Dihydromyricetin mitigates abdominal aortic aneurysmActa pharmaceutica Sinica. B · 2025
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 5 institutions in 3 countries.

Cong-Lin Liu *Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, China (C.L., Y.W., J.Z., G.-P.S.).
Xin Liu *Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.L., X.L., Y.Z., J.L., C.Y., S.L., T.L., Y.W., G.K.S., P.L., J.G., G.-P.S.).
Yuanyuan ZhangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.L., X.L., Y.Z., J.L., C.Y., S.L., T.L., Y.W., G.K.S., P.L., J.G., G.-P.S.).
Jing LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.L., X.L., Y.Z., J.L., C.Y., S.L., T.L., Y.W., G.K.S., P.L., J.G., G.-P.S.).
Chongzhe YangDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.L., X.L., Y.Z., J.L., C.Y., S.L., T.L., Y.W., G.K.S., P.L., J.G., G.-P.S.).
Songyuan LuoDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.L., X.L., Y.Z., J.L., C.Y., S.L., T.L., Y.W., G.K.S., P.L., J.G., G.-P.S.).
Tianxiao LiuDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.L., X.L., Y.Z., J.L., C.Y., S.L., T.L., Y.W., G.K.S., P.L., J.G., G.-P.S.).
Yunzhe WangDepartment of Cardiology, the First Affiliated Hospital of Zhengzhou University, China (C.L., Y.W., J.Z., G.-P.S.).
Jes S LindholtDepartment of Cardiothoracic and Vascular Surgery (J.S.L.), Odense University Hospital, Denmark.
Axel DiederichsenElitary Research Centre of Personalised Medicine in Arterial Disease (CIMA) (J.S.L., A.D., L.M.R.), Odense University Hospital, Denmark.
Lars M RasmussenElitary Research Centre of Personalised Medicine in Arterial Disease (CIMA) (J.S.L., A.D., L.M.R.), Odense University Hospital, Denmark.
Marie DahlCardiovascular Research Unit, Viborg Hospital, Denmark (J.S.L., M.D.).
Galina K SukhovaDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.L., X.L., Y.Z., J.L., C.Y., S.L., T.L., Y.W., G.K.S., P.L., J.G., G.-P.S.).
Guanyi LuDepartment of Surgery, University of Florida Health System, Gainesville, FL (G.L., G.R.U.).
Gilbert R UpchurchDepartment of Surgery, University of Florida Health System, Gainesville, FL (G.L., G.R.U.).
Peter LibbyDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.L., X.L., Y.Z., J.L., C.Y., S.L., T.L., Y.W., G.K.S., P.L., J.G., G.-P.S.).
Junli GuoDepartment of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (C.L., X.L., Y.Z., J.L., C.Y., S.L., T.L., Y.W., G.K.S., P.L., J.G., G.-P.S.).
Jinying ZhangDepartment of Cardiology, the First Affiliated Hospital of Zhengzhou University, China (C.L., Y.W., J.Z., G.-P.S.).
Guo-Ping ShiDepartment of Cardiology, the First Affiliated Hospital of Zhengzhou University, China (C.L., Y.W., J.Z., G.-P.S.).
Brigham and Women's Hospital · USOdense University Hospital · DKUniversity of Florida Health · USFirst Affiliated Hospital of Zhengzhou University · CNRegionshospitalet Viborg · DK

Funding

Role of mast cells in obesityR01HL060942 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI SHI, GUO-PING · 1999 to 2019
$5.6M
Molecular Determinants of Arterial Remodeling in AtherogenesisR01HL080472 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2005 to 2018
$5.0M
Role of Mast cells in Alzheimer's DiseaseR01AG063839 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2020 to 2024
$3.1M
Role of ILC2 and eosinophils in abdominal aortic aneurysmR01HL151627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 2021 to 2024
$2.7M
Inflammatory Mechanisms of AtherosclerosisR01HL034636 · NHLBI · TUFTS UNIVERSITY BOSTON · PI LIBBY, PETER · 1985 to 2006
$1.9M
Role of a novel IL18 binding protein in atherosclerosisR01HL123568 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SHI, GUO-PING · 2015 to 2018
$1.7M
CONTROL OF GROWTH OF VASCULAR WALL CELLSR37HL034636 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LIBBY, PETER · 1993 to 2002
$1.2M
NHLBI NIH HHS R01 HL034636NHLBI NIH HHS R01 HL060942NHLBI NIH HHS R01 HL080472NHLBI NIH HHS R01 HL123568NHLBI NIH HHS R01 HL151627NHLBI NIH HHS R37 HL034636NIA NIH HHS R01 AG063839
6 · The paper itself

Abstract

rationaleBlood eosinophil count and ECP (eosinophil cationic protein) associate with human cardiovascular diseases. Yet, whether eosinophils play a role in cardiovascular disease remains untested. The current study detected eosinophil accumulation in human and murine abdominal aortic aneurysm (AAA) lesions, suggesting eosinophil participation in this aortic disease.

objectiveTo test whether and how eosinophils affect AAA growth. METHODS AND

resultsPopulation-based randomized clinically controlled screening trials revealed higher blood eosinophil count in 579 male patients with AAA than in 5063 non-AAA control (0.236±0.182 versus 0.211±0.154, 10

conclusionsEosinophils play a protective role in AAA by releasing IL4 and cationic proteins such as mEar1 to regulate macrophage and monocyte polarization and to block NF-κB activation in aortic inflammatory and vascular cells.

Indexed as

Vascular RemodelingAdoptive TransferAgedAngiotensin IIAnimalsAorta, AbdominalAortic Aneurysm, AbdominalCells, CulturedDilatation, PathologicDisease Models, AnimalEosinophilsFemaleHumansInflammation MediatorsInterleukin-10Interleukin-4Angiotensin IIEar1 protein, mouseIL10 protein, mouseIl4 protein, mouseInflammation MediatorsInterleukin-10Interleukin-4NF-kappa BRibonucleasescardiovascular diseaseeosinophilinflammationinterleukinmonocyte

Identifiers

PMID33153394
PMCPMC7855167
OpenAlexW3095623534

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.