Evidence map›Paper›PMID 33153376›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2021

A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models.

Niloufar Zarghami, Manuel Sarmiento Soto, Francisco Perez-Balderas, Alexandre A Khrapitchev, Christina Simoglou Karali, Vanessa A Johanssen, Olaf Ansorge, James R Larkin, Nicola R Sibson

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. The origin of brain malignancies at the blood-brain barrier.Cellular and molecular life sciences : CMLS · 2023
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. In vivo methods for imaging blood-brain barrier function and dysfunction.European journal of nuclear medicine and molecular imaging · 2023
    Review
  9. Article
  10. Review
  11. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Niloufar ZarghamiCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.ORCID 0000-0001-8520-9660
Manuel Sarmiento SotoCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.
Francisco Perez-BalderasCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.
Alexandre A KhrapitchevCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.ORCID 0000-0002-7616-6635
Christina Simoglou KaraliCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.
Vanessa A JohanssenCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.
Olaf AnsorgeDepartment of Clinical Neuropathology, John Radcliffe Hospital, Oxford, UK.
James R LarkinCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.ORCID 0000-0002-4169-8447
Nicola R SibsonCancer Research UK and Medical Research Council Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, UK.
Cancer Research UK · GBJohn Radcliffe Hospital · GB

Funding

Cancer Research UK 16945Medical Research Council MR/L022656/1
6 · The paper itself

Abstract

Molecular magnetic resonance imaging (MRI) allows visualization of biological processes at the molecular level. Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in neurological disease. The aim of this study, therefore, was to develop a novel molecular MRI contrast agent, by conjugating anti-ALCAM antibodies to microparticles of iron oxide (MPIO), for detection of endothelial ALCAM expression

Indexed as

Activated-Leukocyte Cell Adhesion MoleculeAdenocarcinoma of LungAnimalsAntibodies, MonoclonalApoptosisBrain NeoplasmsBreast NeoplasmsCell ProliferationContrast MediaFemaleFerric CompoundsHumansLung NeoplasmsMagnetic Resonance ImagingMelanomaMiceActivated-Leukocyte Cell Adhesion MoleculeAntibodies, MonoclonalContrast MediaFerric Compoundsferric oxideactivated leukocyte cell adhesion molecule (ALCAMbrain metastasisCD166)inflammationMagnetic resonance imagingmolecular imaging

Identifiers

PMID33153376
PMCPMC8217895
OpenAlexW3095643599

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.