Evidence map›Paper›PMID 33153368›Full record

ArticleJournal of medical screening2021

Morbidity and mortality after major large bowel resection of non-malignant polyp among participants in a population-based screening program.

Lawrence F Paszat, Rinku Sutradhar, Jin Luo, Nancy N Baxter, Jill Tinmouth, Linda Rabeneck

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical screening, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 53% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Lawrence F PaszatInstitute for Health Care Policy, Management and Evaluation, University of Toronto, Toronto, Canada.ORCID 0000-0002-3595-1493
Rinku SutradharInstitute for Health Care Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
Jin LuoCancer Program, Institute for Clinical Evaluative Sciences, Toronto, Canada.
Nancy N BaxterInstitute for Health Care Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
Jill TinmouthInstitute for Health Care Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
Linda RabeneckInstitute for Health Care Policy, Management and Evaluation, University of Toronto, Toronto, Canada.
University of Toronto · CAInstitute for Clinical Evaluative Sciences · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsColonoscopy following positive fecal occult blood screening may detect non-malignant polyps deemed to require major large bowel resection. We aimed to estimate the major inpatient morbidity and mortality associated with major resection of non-malignant polyps detected at colonoscopy following positive guaiac fecal occult blood screening in Ontario's population-based colorectal screening program.

methodsWe identified those without a diagnosis of colorectal cancer in the Ontario Cancer Registry ≤24 months following the date of colonoscopy prompted by positive fecal occult blood screening between 2008 and 2017, who underwent a major large bowel resection ≤24 months after the colonoscopy, with a diagnosis code for non-malignant polyp, in the absence of a code for any other large bowel diagnosis. We extracted records of major inpatient complications and readmissions ≤30 days following resection. We computed mortality within 90 days following resection.

resultsFor those undergoing colonoscopy ≤6 months following positive guaiac fecal occult blood screening, 420/127,872 (0.03%) underwent major large bowel resection for a non-malignant polyp. In 50/420 (11.9%), the resection included one or more rectosigmoid or rectal polyps, with or without a colonic polyp. There were one or more major inpatient complications or readmissions within 30 days in 117/420 (27.9%). Death occurred within 90 days in 6/420 (1.4%).

conclusionsSerious inpatient complications and readmissions following major large bowel resection for non-malignant colorectal polyps are common, but mortality ≤90 days following resection is low. These outcomes should be considered as unintended adverse consequences of population-based colorectal screening programs.

Indexed as

Colonic PolypsColorectal NeoplasmsColectomyColonoscopyHumansMorbidityOccult Bloodmajor large bowel resectionmajor postoperative complicationspopulation-based colorectal screening programpostoperative mortalityScreen-detected polyp

Identifiers

PMID33153368
PMCPMC8366188
OpenAlexW3095276236

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.