Evidence map›Paper›PMID 33153214›Full record

ArticleInternational journal of molecular sciences2020

Cyclin Y is expressed in Platelets and Modulates Integrin Outside-in Signaling.

Anastasia Kyselova, Mauro Siragusa, Julian Anthes, Fiorella Andrea Solari, Stefan Loroch, René P Zahedi, Ulrich Walter, Ingrid Fleming, Voahanginirina Randriamboavonjy

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The role of cyclin Y in normal and pathological cells.Cell cycle (Georgetown, Tex.) · 2023
    Review
  3. Molecular Research on Platelet Activity in Health and Disease 2.0.International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Anastasia KyselovaInstitute for Vascular Signaling, Centre of Molecular Medicine, Goethe University, Frankfurt am Main, 60590 Frankfurt, Germany.
Mauro SiragusaInstitute for Vascular Signaling, Centre of Molecular Medicine, Goethe University, Frankfurt am Main, 60590 Frankfurt, Germany.
Julian AnthesInstitute for Vascular Signaling, Centre of Molecular Medicine, Goethe University, Frankfurt am Main, 60590 Frankfurt, Germany.
Fiorella Andrea SolariLeibniz-Institute for Analytical Sciences (ISAS)- e.V., Otto-Hahn-Str. 6b, 44227 Dortmund, Germany.ORCID 0000-0003-3199-6296
Stefan LorochGerman Center of Cardiovascular Research (DZHK), Partner site Rhein Main, 17475 Greifswald, Germany.
René P ZahediGerman Center of Cardiovascular Research (DZHK), Partner site Rhein Main, 17475 Greifswald, Germany.
Ulrich WalterGerman Center of Cardiovascular Research (DZHK), Partner site Rhein Main, 17475 Greifswald, Germany.
Ingrid FlemingInstitute for Vascular Signaling, Centre of Molecular Medicine, Goethe University, Frankfurt am Main, 60590 Frankfurt, Germany.
Voahanginirina RandriamboavonjyInstitute for Vascular Signaling, Centre of Molecular Medicine, Goethe University, Frankfurt am Main, 60590 Frankfurt, Germany.
Goethe University Frankfurt · DELeibniz Institute for Analytical Sciences - ISAS · DEJohannes Gutenberg University Mainz · DE

Funding

Deutsche Forschungsgemeinschaft RA 2435/3-2, FL 364/7-1Deutsches Zentrum für Herz-Kreislauf-Forschung eV DZHK 81X2200113
6 · The paper itself

Abstract

Diabetes is associated with platelet hyper-reactivity and enhanced risk of thrombosis development. Here we compared protein expression in platelets from healthy donors and diabetic patients to identify differentially expressed proteins and their possible function in platelet activation. Mass spectrometry analyses identified cyclin Y (CCNY) in platelets and its reduced expression in platelets from diabetic patients, a phenomenon that could be attributed to the increased activity of calpains. To determine the role of CCNY in platelets, mice globally lacking the protein were studied.

Indexed as

AdultAnimalsBlood PlateletsCyclinsFemaleHumansIntegrinsMaleMiceMice, Inbred C57BLMice, KnockoutMiddle AgedPlatelet ActivationPlatelet AdhesivenessPlatelet AggregationSignal TransductionCCNY protein, humanCyclinscyclin Y, mouseIntegrinscyclin Yintegrinoutside-in signalingspreading

Identifiers

PMID33153214
PMCPMC7662234
OpenAlexW3097285924

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.